Page:United States Statutes at Large Volume 100 Part 2.djvu/535

 PUBLIC LAW 99-499—OCT. 17, 1986

100 STAT. 1637

significant risk to human health of acute, subacute, and chronic health effects. "(C) Where appropriate, an identification of toxicological testing needed to identify the types or levels of exposure that may present significant risk of adverse health effects in humans. Any toxicological profile or revision thereof shall reflect the Administrator of ATSDR's assessment of all relevant toxicological testing which has been peer reviewed. The profiles required to be prepared under this paragraph for those hsizardous substances listed under subparagraph (A) of paragraph (2) shall be completed, at a rate of no fewer than 25 per year, within 4 years after the enactment of the Superfund Amendments and Reauthorization Act of 1986. A profile required on a substance listed pursuant to subparagraph (B) of paragraph (2) shall be completed within 3 years after addition to the list. The profiles prepared under this paragraph shall be of those substances highest on the list of priorities under paragraph (2) for which profiles have not previously been prepared. Profiles required under this paragraph shall be revised and republished as necessary, but no less often than once every 3 years. Such profiles shall be provided to the States and made available to other interested parties. "(4) The Administrator of the ATSDR shall provide consultations State and local upon request on health issues relating to exposure to hazardous or governments. toxic substances, on the basis of available information, to the Administrator of EPA, State officials, and local officials. Such consultations to individuals may be provided by States under cooperative agreements established under this Act. "(5)(A) For each hazardous substance listed pursuant to paragraph Research and (2), the Administrator of ATSDR (in consultation with the Adminis- development. trator of EPA and other agencies and programs of the Public Health Service) shall assess whether adequate information on the health effects of such substance is available. For any such substance for which adequate information is not available (or under development), the Administrator of ATSDR, in cooperation with the Director of the National Toxicology Program, shall assure the initiation of a program of research designed to determine the health effects (and techniques for development of methods to determine such health effects) of such substance. Where feasible, such program shall seek to develop methods to determine the health effects of such substance in combination with other substances with which it is commonly found. Before assuring the initiation of such program, the Administrator of ATSDR shall consider recommendations of the Interagency Testing Committee established under section 4(e) of the Toxic Substances Control Act on the types of research that should be done. 15 USC 2603. Such program shall include, to the extent necessary to supplement existing information, but shall not be limited to— "(i) laboratory and other studies to determine short, intermediate, and long-term health effects; "(ii) laboratory and other studies to determine organ-specific, site-specific, and system-specific acute and chronic toxicity; "(iii) laboratory and other studies to determine the manner in which such substances are metabolized or to otherwise develop an understanding of the biokinetics of such substances; and "(iv) where there is a possibility of obtaining human data, the collection of such information.

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