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14 granular protoplasm (Fig. 8). At first the hæmozoin particles in the crescent, in the oval body, and in the sphere are motionless and central; more rarely they are eccentric. By and by, in many of the spheres these particles tend to arrange themselves as a ring, lying in contact with the inner surface of what may be a very fine, invisible membrane, occupying

Fig. 8.—Subtertian parasite, showing male and female gametes approximated. (From a preparation by Dr. F. W. O'Connor.)

the central third of the sphere, and forming, as it were, a small central sphere within the larger sphere. After a time in the hyaline spheres the hæmozoin particles begin—at first slowly and intermittently, afterwards more energetically—to dance about. As the movement of the pigment increases in rapidity and energy the entire sphere seems to partake in the agitation—to quiver, to change form, and to be jerked about as by some unseen force. The hæmozoin particles