Page:Treatise on poisons in relation to medical jurisprudence, physiology, and the practice of physic (IA treatiseonpoison00chriuoft).pdf/390

 supernitrate being left in solution, and the trisnitrate thrown down in the form of a white powder.

Orfila found that the soluble part of fifteen grains of the nitrate, when injected into the jugular vein of a dog, caused immediate giddiness and staggering, and death in eight minutes. He also remarked that forty grains mixed with water and introduced into the stomach, caused all the customary signs of irritation, and death in twenty-four hours; and that a great part of the villous coat of the stomach was reduced to a pulpy mass, and likewise exhibited several ulcers.

Similar effects were produced by the trisnitrate; but a larger dose was required. Two drachms and a half killed a dog in twenty-four hours; and redness and eroded spots were found in the stomach.

In some more recent researches Orfila found that the poison is absorbed, and may be detected, like other metallic poisons, in the liver, spleen, and urine. The process for this purpose, applicable also to all organic mixtures, consists in boiling the solids in water acidulated with a twentieth of nitric acid, evaporating the solution to dryness, charring the residue with nitric acid, as directed for copper, boiling the charcoal in diluted nitric acid, and thus obtaining an acid solution of nitrate of bismuth, which may be known by the effects of water and of hydrosulphuric acid.

Orfila remarks, that Camerarius of Tübingen once detected the adulteration of wine with the oxide of bismuth, and that the bakers in some parts of England used to render their bread white and heavy by mixing the trisnitrate with flour; but he has not stated his authority for this accusation. It may be discovered in any such mixture by calcining the suspected substance in a crucible, and then separating the metallic bismuth by means of nitric acid. But the adulteration of bread with bismuth is very questionable, as there are many cheaper methods for effecting the purpose, without adding any thing positively deleterious.

The following is the only case with which I am acquainted of poisoning with the preparations of bismuth in the human subject. A man subject to water-brash took two drachms of the trisnitrate with a little cream of tartar by mistake for a mixture of chalk and magnesia. He was immediately attacked with burning in the throat, brown vomiting, watery purging, cramps, and coldness of the limbs, and intermitting pulse, and then with inflammation of the throat, difficult swallowing, dryness of the membrane of the nose, and a constant nauseous metallic taste. On the third day he had hiccup, laborious breathing, and swelling of the hands and face; and suppression of urine was then discovered to have existed from the first. On the fourth day swelling and tension of the belly were added to the preexisting symptoms, on the fifth day salivation, on the sixth delirium, on the seventh, swelling of the tongue and enormous enlargement of the belly; and on the ninth he expired. The urine continued suppressed till the eighth day.—On inspection of the body it was found that from the back of the mouth to the rectum there were but few points