Page:Treatise on poisons in relation to medical jurisprudence, physiology, and the practice of physic (IA treatiseonpoison00chriuoft).pdf/333

 in man by mercurial poisons generally. Returning now to its mode of action, we have to examine its relative effects through the different animal textures, and in its various chemical forms.

The result of the previous remarks as to its action on animals, it will be remembered, was, that its soluble preparations cause when swallowed corrosion of the stomach, and in whatever way it enters the body irritation of the stomach and rectum, inflammation of the lungs, depressed action and perhaps inflammation of the heart, oppression of the functions of the brain, and inflammation of the salivary glands. All of these effects have likewise been mentioned in the preceding sketch, as occurring in a greater or less degree in consequence of its operation on man.

Mercury acts as a poison on man in whatever way it is introduced into the body,—whether it be swallowed, or inhaled in the form of vapour, or applied to a wound, or even simply rubbed or placed on the sound skin. But the kind of action excited differs according to the channel by which it is introduced.

The most ordinary and dangerous cases of poisoning arise from the introduction of corrosive sublimate into the stomach. The poison then kills by corroding or inflaming the alimentary canal, or by causing salivation and its concomitants.

When applied to a wound or ulcer corrosive sublimate does not often occasion dangerous symptoms. Yet it is sometims a hazardous remedy. It is not a convenient escharotic even in a concentrated state; for its escharotic action is not incompatible with its absorption; at all events it certainly sometimes acts constitutionally through the surface of wounds and ulcers, and the symptoms brought on in this way are generally violent. They are the symptoms of mercurial salivation, accompanied at times with well-marked inflammation of the alimentary canal. When applied to sores in a diluted state it has also been known to cause dangerous effects if too long persevered in. A case of the kind has been related by Mr. Robertson, an army-surgeon. After anointing an itchy eruption of the arms for seven days with a solution of corrosive sublimate containing five grains to the ounce, his patient was attacked with fever, inflammation of the stomach and bowels, and in two days more with violent salivation. A case of the same nature has been related by Mr. Sutleffe. His patient, a child, in consequence of having an eruption of the head washed with a solution of corrosive sublimate, was attacked with violent salivation, which proved fatal in a few days. Pibrac has recorded three fatal cases from the free application of corrosive sublimate to ulcerated surfaces. One of these proved fatal in five days, another in twenty-four hours, and a third during the night after the poison was applied. The symptoms generally indicated violent action on the alimentary canal. In an instance mentioned by Degner, fatal in twenty-five days, there was also violent irritation