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 dubiously,—produce, when injected into the jugular vein, obstruction of the capillaries of the pulmonary circulation, and consequently asphyxia. This is proved by the hæmadynamometer introduced into a vein indicating great increase of pressure in the venous circulation a few seconds after the introduction of the poison; by this instrument introduced into the femoral artery indicating great diminution of arterial pressure, although the heart continues to beat vigorously; by the breathing becoming at the same time laborious, without the heart suffering; by these symptoms preceding any signs of action on the nervous system; by the heart pulsating for some time after death; and in many instances by frothy mucus having accumulated in the air-passages, and congestion and extravasation having taken place in the lungs themselves.

A great number of the poisons whose action is remote, operate on the brain. The most decided proof of such an action is the nature of the symptoms; which are, giddiness, delirium, insensibility, convulsions, palsy, coma. Some physiologists have also sought for evidence in the body after death, and have imagined they found it in congestion of the vessels in the brain, and even extravasation of blood there; but it will be seen under the head of Narcotic Poisons that such appearances are far from being essential, and indeed are seldom witnessed. All narcotic poisons act on the brain, and most narcotico-acrids too; but very frequently other organs are affected at the same time, and in particular the spine and heart.

The influence of poisons on the brain seems to be sometimes induced, not immediately, but indirectly through the intervention of a more direct influence on the pulmonary circulation. Thus Mr. Blake appears to have succeeded in proving that the insensibility and tetanic convulsions which immediately precede death, when certain substances, such as the salts of soda, are injected into the veins, depend simply on the obstruction directly produced in the pulmonary circulation causing increased pressure in the systemic veins, and consequently upon the brain and nervous centre generally. For when the jugular vein was opened after the development of tetanic convulsions, and blood was allowed to flow out, the nervous symptoms ceased, and the animal continued for two hours sensible and without any return of convulsions, dying eventually of hemorrhage. But more generally the effect produced on the brain is direct and specific. Thus opium and its active principle morphia suspend the functions of external relation, which are peculiarly dependent on the brain; while for a long time the respiration and circulation are little affected. Even when the poison is admitted directly into the veins, the pulmonary capillaries are not obstructed, and the heart is only somewhat enfeebled in its contractions; and in ordinary cases of poisoning with these substances the heart continues to pulsate, and the lungs also discharge their office, long after sensibility is extinguished and voluntary motion arrested,—until at length the circulation and re-*