Page:Treatise on poisons in relation to medical jurisprudence, physiology, and the practice of physic (IA treatiseonpoison00chriuoft).pdf/19

 These observations being held in view, it is impossible to doubt, that some organs sympathize with certain impressions made on others at a distance; nor can we imagine any other mode of conveyance for these impressions except along the nerves. The question, then, comes to be what are the impressions that may be so transmitted?

The statements already made will prepare us to expect a sympathetic action in the case of poisons that manifestly injure the structure of the organ to which they are applied. In the instance of the pure corrosives its existence may be presumed from the identity of the phenomena of their remote action with those of natural disease or mechanical injury. It was stated above that the mineral acids when swallowed often prove fatal in a very short space of time; and here, as in mere injury from disease or violence, the symptoms are an imperceptible pulse, fainting, and mortal weakness. Remote organs therefore must be injured; and from the identity of the phenomena with those of idiopathic affections of the stomach, even if there were no other proof, it might be presumed that the primary impression is conveyed along the nerves. We are not restricted, however, to such an argument: The presumptive inference is turned to certainty by the effect of dilution on the activity of these poisons. Dilution materially lessens or even takes away altogether the remote action of the mineral acids. Now dilution facilitates, instead of impeding their absorption: consequently they do not act on remote organs through that channel. There is no other way left by which we can conceive them to act, except by conveyance of the local impression along the nerves.—As to the irritants that are not corrosive, it can hardly be doubted, since they inflame the stomach, that the usual remote effects of inflammation will ensue, namely, a sympathetic injury of distant organs.

But it remains to be considered, whether distant organs may sympathize also with the peculiar local impressions called nervous,—which are not accompanied by any visible derangement of structure. This variety of action by sympathy is the one which has chiefly engaged the attention of toxicologists; and it has been freely resorted to for explaining the effects of many poisons. Nevertheless its existence is doubtful.

The only important arguments in support of the sympathetic action of poisons are, that unequivocal instances exist of local nervous impressions being conveyed to a limited extent along the nerves,—and that the rapidity of the effects of some poisons is so great as to be incompatible with any other medium of action except the nervous system.

In the first place it is maintained, that a limited nervous transmission, that is, the conveyance of a local impression, purely functional in its nature, to parts at a short distance from the texture acted on directly, must occur in some instances,—as, for example, in the action of belladonna in dilating the pupil when applied to the conjunctiva of the eye, and in the effect of opium in allaying deep-seated pain when applied to the integuments over the affected part. It is by no means