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 be remarked, however, that few published cases contain good histories of the symptoms; since they commonly come to an end before being seen by the physician. Convulsions appear to have occurred in some instances either at the time of death or soon before it. In the slower cases various nervous affections have been observed. A girl, who swallowed by mistake about two drachms, and did not vomit till emetics were given, complained much at first of pain, but afterwards chiefly of great lassitude and weakness of the limbs, and next morning of numbness and weakness there as well as in the back. This affection was at first so severe that she could hardly walk up stairs; but in a few days she recovered entirely. Analogous effects took place in Mr. Hebb's patient and in Dr. Arrowsmith's case. The first thing the former complained of was acute pain in the back, gradually extending down the thighs, occasioning ere long great torture, and continuing almost till the moment of death. Dr. Arrowsmith's patient had the same symptoms, complained more of the pain shooting down from the loins to the limbs than of the pain in the belly, and was constantly seeking relief in a fresh change of posture. Mr. Frazer's patient had from an early period a peculiar general numbness, approaching to palsy. Dr. Babington's patient, who took two scruples by mistake for tartaric acid in an effervescing draught, suffered, after the first twenty-four hours, chiefly from headache, extreme feebleness of the pulse, and a sense of numbness and tingling or pricking in the back and thighs. In a recent case described by Mr. Tapson, which occurred in London, and where it was supposed, but on insufficient grounds, that so much as two ounces had been taken, violent symptoms of irritation in the alimentary canal came on as usual, but soon afterwards a sense as if the hands were dead, loss of consciousness for eight hours, and then lividity, coldness, and almost complete loss of the power of motion in the legs; which symptoms were not entirely removed for fifteen days. In a case related by Mr. Alfred Taylor, where death was caused by seven drachms in fifteen or twenty minutes, there was first violent vomiting, then severe pain in the stomach, and finally clammy perspiration and convulsions, with two or three deep inspirations before death. The effects in this case came very near those generally observed in animals.

In Dr. Arrowsmith's case two symptoms occurred, which I have not seen mentioned in any other. The first was an eruption or mottled appearance of the skin in circular patches, not unlike the roundish red marks on the arms of stout healthy children, but of a deeper tint. The second was the poisoning and death of leeches applied to the stomach. "They were healthy," says Dr. Arrowsmith in the notes with which he obligingly furnished me, "small, and fastened