Page:Transactions of the Royal Society of Tropical Medicine and Hygiene, volume 1.djvu/38



{{c|{Read by Dr. M. NIERENSTEIN, Wednesday, July lOth, 1907.)}}

therapeutics of the present time for trypanosomiasis can be divided into the following:—
 * A. Arsenic Compounds.—1. Arsenious acid; 2. Fowler's solution.
 * B. Colours.—1. Colouring matters belonging to the diazo group, Ehrlich's trypanred and Mesnil's afrodol blue and afrodol violet; 2. Colouring matters belonging to the triphenyl-methan groups, Ehrlich's malachite green and fuchsin.
 * C. Atoxyl, which being an organic compound of aniline and arsenious acid cannot be considered as merely "an arsenic compound," an expression recently used in the lay Press.

The introduction of an acid radicle into an amido nucleus generally changes its basic character, and, of course, on the other hand, lessens the acidity. The combined effect of aniline and arsenic is, therefore, the resultant of these two factors : amido group and arsenious acid. We have been able to demonstrate experimentally that either the amount of aniline generally given in the form of atoxyl, or the arsenious acid contained in that drug, when administered alone, will kill an animal within a few hours after the injection.


 * D. Combined Treatment.—1. Combination of arsenious or acid atoxyl with colouring matters, as trypanred, suggested by Thomas and Breinl, Laveran and Mesnil, and