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The problem which was already being mooted by such scientific men as Ramsay, Rutherford, and Soddy, in the very beginning of the twentieth century, the problem of inducing radio-activity in the heavier elements and so tapping the internal energy of atoms, was solved by a wonderful combination of induction, intuition, and luck by Holsten so soon as the year 1933. From the first detection of radio-activity to its first subjugation to human purpose measured little more than a quarter of a century. For twenty years after that, indeed, minor difficulties prevented any striking practical application of his success, but the essential thing was done, this new boundary in the march of human progress was crossed, in that year. He set up atomic disintegration in a minute particle of bismuth; it exploded with great violence into a heavy gas of extreme radio-activity, which disintegrated in its turn in the course of seven days, and it was only after another