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bruised, and that the pericranium in this region had been laid bare. During the first three days following the accident the patient manifested only a moderate degree of fever, but on the fourth day the fever became more pronounced. The wound, which by this time was discharging actively, presented at first a healthy appearance, but it soon acquired an unhealthy aspect, and the patient began to complain of numbness in the right leg. Vesalius, the private physician of Charles the Fifth, the boy's grandfather, was one of the many physicians who were called in to consult about the treatment of this case; he was sent for on the eleventh day following the accident. On the seventeenth day the wound was enlarged and the bone carefully examined, but no evidence of a fracture or a fissure was discovered. On the following day erysipelas manifested itself on the head and neck and extended downward until it had involved both arms. At the same time the fever increased very markedly, and for five days the patient was delirious. As by this time there was ample reason for suspecting that some intracranial injury had occurred, it was decided to trephine the skull. The operation was performed on the twenty-first day, but nothing of importance was discovered. The patient's life was now evidently in great peril, and an unfavorable prognosis was pronounced. Four days later, however, complete consciousness returned. On the twenty-ninth day a quantity of pus was evacuated from the very much swollen eyelids; and, three days later still, the patient was found to be quite free from fever. On the forty-sixth day he left his bed for the first time, and at the end of ninety-three days the wound was found to have firmly cicatrized.

[Some interesting details concerning the subsequent life of Don Carlos will be found in Motley's "Rise of the Dutch Republic." They suggest the possibility that his attacks of violent temper may have resulted from the lesions produced by the accident narrated above.]

Francisco Arceo was born, about the year 1493, at Fregenal in the Province of Badajoz, Spain. It is not known at what university or other educational institution he received his early training in the science of medicine. It is a well-established fact, however, that at quite an early stage of his professional career he acquired great celebrity for his skill in treating both surgical and internal maladies, and that, as a consequence, patients flocked in large numbers