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 much importance, since it must determine in a great measure the period of arrival. Those persons who expect to take up their residence in New York, Boston, or any of the Atlantic towns and cities, should embark as soon as possible after the middle or close of January, that they may arrive at the breaking up of winter, which is the opening of the business season in those cities; this time affords the best chance of employment, as the tide of emigration has but then commenced. Those who intend to reside in New Orleans, or in any of the Southern cities or towns, should make an effort to land by the middle of November or soon afterwards: business then opens in those places, and the prevailing and dangerous epedemic, yellow fever, has subsided or disappeared. The length of time passed in those places, the longer it be before the next return of the sickly season, the more the stranger becomes acclimated and capable of supporting the trying ordeal of the intense heat of summer and the scourge it generally brings. The yellow fever, generally commences at New Orleans in the beginning of July, sometimes later, and ends towards the beginning of November. The first slight frosts are said by the inhabitants of New Orleans to be the signal for its departure. Unacclimated persons comprise the greatest proportion of its victims; and on this account emigrants who intend to reside here or only make it a point in passing up the Mississippi, should know how to take advantage of the most favorable time to effect a landing. Those intending to make the interior of Pennsylvania, Virginia, Southern Ohio, Kentucky, Indiana, Illinois or Missouri,