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Spanish conquerors were captivated by the charms of Inca princesses and their attendants at Cuzco. Three daughters of Huayna Ccapac had Spanish husbands. Beatriz Ñusta married Mancio Serra de Leguisamo, one of the conquerors, to whom much interest attaches owing to his remarkable will. Another, BeatrizInez [sic] Ñusta, was the wife of Martin de Mustincia, and secondly of Diego Hernandez. Inez Ñusta had two children by Francisco Pizarro. A niece of Huayna Ccapac, named Francisca Nusta, married Juan de Collantes, and was ancestress of Bishop Piedrahita the historian. Angelina, daughter of Atahualpa, married Juan de Betanzos, the author and Quichua scholar.

Hualpa Tupac Yupanqui, the next brother of the Inca Huayna Ccapac, had a son of the same names, and a daughter named Isabel Yupanqui Ñusta, the wife of the Spanish knight, Garcilasso de la Vega, and mother of the famous Inca historian. Paullu Tupac Yupanqui, the brother of the Inca Manco, had thrown in his lot with the Spaniards, was baptised with the name of