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 Note 1, page 1. Dom, (born about 1490; died 1556), was the second son of Diego de Silva and Maria de Ayola, Count and Countess of Portalegre, a province of central Portugal. Having studied at the universities of Paris, Siena and Bologna, he was soon called to the court of Emanuel of Portugal, held various ecclesiastical posts, and was made Bishop of Viseu in the Province of Beira. As ambassador to Popes Leo X, Adrian VI and Clement VII, he paid long visits to Rome, where his friendship with Castiglione probably began. During the twenty years that followed 1521 he served John III of Portugal as Escribano de la Puridad; then, having been made a cardinal by Paul III, he spent the remainder of his life in the papal service, died in Rome, and was buried in the church of Santa Maria in Trastevere. Eminent as a prelate and a diplomatist, he also enjoyed no small repute as an author and an elegant Latinist. Note 2, page 1. , Duke of Urbino, (born 1472; died 1508), was the only son of Duke Federico di Montefeltro and Battista Sforza, an accomplished niece of the first Sforza duke of Milan. Precocious as a child, he was elaborately yet judiciously educated, and much of the praise bestowed upon him in is shown by contemporary evidence to have been just. On his father's death in 1482, both he and his State were confided to his cousin Ubaldini (see note 273), who seems to have been loyal to the trust, although next heir to the duchy. From records that have survived, Dennistoun extracts some details of the young duke's court: "To all persons composing the ducal household, unexceptionable manners were indispensable. In those of higher rank there were further required competent talents and learning, a grave deportment, and fluency of speech. The servants must be of steady habits and respectable character; regular in all private transactions; of good address, modest and graceful; willing and neat handed in their service. There is likewise inculcated the most scrupulous personal cleanliness, especially of the hands, with particular injunctions as to frequent ablutions, and extraordinary precautions against the unpleasant effects of hot weather on their persons and clothing; in case of need, medical treatment is enjoined to correct the breath. Those who wore livery had two suits a year, generally of fustian, though to some silk doublets were given for summer use."

In 1489 Guidobaldo married Elisabetta Gonzaga, a sister of the Marquess of Mantua. All hopes, however, of an heir were soon abandoned, apparently owing to the young duke's physical infirmities, which were increased by over exercise and in time unfitted him for all active occupations. Nevertheless he was able to take part in the vain resistance to Charles VIII's invasion of Italy, and later in the expulsion of the French from the kingdom of Naples. While