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Rh mercury, and known laws of the human body, and by reasoning from these, would attempt to discover whether mercury will act upon the body when in the morbid condition supposed, in such a manner as would tend to restore health. The experimental method would simply administer mercury in as many cases as possible, noting the age, sex, temperament, and other peculiarities of bodily constitution, the particular form or variety of the disease, the particular stage of its progress, etc., remarking in which of these cases it was attended with a salutary effect, and with what circumstances it was on those occasions combined. The method of simple observation would compare instances of recovery, to find whether they agreed in having been preceded by the administration of mercury; or would compare instances of recovery with instances of failure, to find cases which, agreeing in all other respects, differed only in the fact that mercury had been administered, or that it had not.

§ 7. That the last of these three modes of investigation is applicable to the case, no one has ever seriously contended. No conclusions of value on a subject of such intricacy ever were obtained in that way. The utmost that could result would be a vague general impression for or against the efficacy of mercury, of no avail for guidance unless confirmed by one of the other two methods. Not that the results, which this method strives to obtain, would not be of the utmost possible value if they could be obtained. If all the cases of recovery which presented themselves, in an examination extending to a great number of instances, were cases in which mercury had been administered, we might generalize with confidence from this experience, and should have obtained a conclusion of real value. But no such basis for generalization can we, in a case of this description, hope to obtain. The reason is that which we have spoken of as constituting the characteristic imperfection of the Method of Agreement, Plurality of Causes. Supposing even that mercury does tend to cure the disease, so many other causes, both natural and artificial, also tend to cure it, that there are sure to be abundant instances of recovery in which mercury has not been administered, unless, indeed, the practice be to administer it in all cases; on which supposition it will equally be found in the cases of failure.

When an effect results from the union of many causes, the share which each has in the determination of the effect can not in general be great, and the effect is not likely, even in its presence or absence, still less in its variations, to follow, even approximately, any one of the causes. Recovery from a disease is an event to which, in every case, many influences must concur. Mercury may be one such influence; but from the very fact that there are many other such, it will necessarily happen that although mercury is administered, the patient, for want of other concurring influences, will often not recover, and that he often will recover when it is not administered, the other favorable influences being sufficiently powerful without it. Neither, therefore, will the instances of recovery agree in the administration of mercury, nor will the instances of failure agree in its non-administration. It is much if, by multiplied and accurate returns from hospitals and the like, we can collect that there are rather more recoveries and rather fewer failures when mercury is administered than when it is not; a result of very secondary value even as a guide to practice, and almost worthless as a contribution to the theory of the subject.