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Three interpretations have been offered of the words ‘He has no children.’

(a) They refer to Malcolm, who, if he had children of his own, would not at such a moment suggest revenge, or talk of curing such a grief. Cf. King John, iv. 91, where Pandulph says to Constance,

and Constance answers,

(b) They refer to Macbeth, who has no children, and on whom therefore Macduff cannot take an adequate revenge.

(c) They refer to Macbeth, who, if he himself had children, could never have ordered the slaughter of children. Cf. 3 Henry VI. v. 63, where Margaret says to the murderers of Prince Edward,

I cannot think interpretation (b) the most natural. The whole idea of the passage is that Macduff must feel grief first and before he can feel anything else, e.g. the desire for vengeance. As he says directly after, he cannot at once ‘dispute’ it like a man, but must ‘feel’ it as a man; and it is not till ten lines later that he is able to pass to the thought of revenge.