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 Charles V, King of Spain and the Netherlands, who had a great regard for the Nassau family, he was sent to Brussels to be educated as a Catholic. Also at the Emperor's request he became a page at his court, and by the time he was fifteen the Emperor had made an intimate friend of him, taking him into his complete confidence, and allowing him to be present at the gravest and most secret conclaves. He would ask William's advice about important matters of State and go by his judgments. This might have been enough to turn the head of any one more than double the boy's age, but it did not appear to spoil William. He seemed only to profit and to put to the best possible use all the knowledge he got of human nature and of public affairs by being, so to speak, behind the scenes in this very confidential and important position. Charles, who took pride in discovering great men, showed in the case of Orange a great deal of insight into character.

When he was eighteen the Emperor gave him a wife, a young girl of noble family, Anne of Egmont. She lived six years and they had two children. Judging by Orange's letters to his wife he must have been a faithful and loving husband, but he could not have seen much of her, as he was nearly always away from home fighting for his master. Charles had made him, at the age of twenty-one, General-in-Chief of his army on the frontier of France, with which country Charles was at war.