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Rh any one that such measures would increase the difficulties and aggravate the complaints they were designed to relieve. Under these circumstances, he seems to have been driven by necessity to make the dose so small as not greatly to aggravate the disorder; and this led him to the use of infinitesimal doses, by which means the system was left undisturbed to overcome its derangement by its own inherent recuperative power. Unassisted Nature did the cure which Hahnemann ascribed to his potions. The infinitesimal dose became a fixed principle with Hahnemann, from which he never departed. In his Organon of Homœopathic Medicine, page 204, he says, "This incontrovertible axiom, founded upon experience, will serve as a rule by which the dose of all homœopathic medicines, without exception, are to be attenuated to such a degree, that after being introduced into the body they shall merely produce an almost insensible aggravation of the disease." In his Organon, page 289, he says, "The very smallest, I repeat, for it holds good as a homœopathic therapeutic maxim, not to be refuted by any experience in the