Page:Proceedings of the Royal Society of London Vol 60.djvu/364

Rh it is shown that this assumption does not introduce any serious error within the limits of volume considered. We then find it possible to integrate the resulting differential equation, and the complete pramtive enables us to draw a set of adiabatic curves. We believe that this is the first time adiabatic carves have been obtained for any substance except perfect gases. . ,, c

A mathematical discussion is added as to what extent the eqnatio Reaction* of certain Synthesised Proteid-likc Substances. 337 and E = g T - h gjl) = constant, cann be considered as strictly true, and not merely approximate

The experimental results for liquid ether form an appendix to the paper.

The experiments of Professor Grimaux,* made more than ten years ago. have until recently attracted but little attention amongst English physiologists, although that investigator has synthesised a series of colloidal substances which, in their chemical characteristics, show striking similarities to proteids.

Working alone, and in collaboration with Professor Halliburton, + have shown that three of the substances synthesised, viz., the « Colloids amidobenzoic A and B,” formed by the interaction of phosphorus pentachloride and meta-amido-benzoic acid at 1-5 U, according to the details described in Grimaux’s papers, and the “ colloide aspartique ” formed by the passage of a current^ of dry gaseous ammonia over solid aspartic anhydride heated to 125 C., not only give the leading chemical reactions of proteids, but when intravenously injected into dogs, cats, or pigmented rabbits, ca-.se extensive intravascular coagulation of the blood, in a manner indistinguishable from the physiological action of nucleo-proteids. A hen injected into the veins of albino rabbits or into the vascular system

ibid., vol. 98, p. 1434 and p. 1578. t Pickering,4 Journ. Physiol.,’ vol. 14, p. 341, 1893 ; ‘ Comptes Rendus, vol. 120, p. 1348, 1895; 4 Physiol. Soc. Proc.,’ Feb. 16, 1895 (‘ Journ. Physiol.,’ vol. 17) ; ‘ Journ.’ Physiol.,’ vol. 18, p. 54, 1895 ; vol. 20, p. 171, 1S9G; ibid., vol. 20, p. 310; Halliburton and Pickering, 4 Journ. Physiol.,’ vol. 18, p. 285, 1895.
 * Grimaux, ‘ Comptes Rendus,’ vol.93, p. 771,1881; ibid., vol, 98, p. 105, 1884;