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 occupied at the end of the seventeenth century. The progress of therapeutics is to be marked, not by the labors of "practical men" (who, by the way, are of all the most theoretical, only that their theories are wrong), but by the, at first sight, unconnected studies of Descartes and Newton, of Hooke and Grew, of Lavoisier and Davy and Volta, of Marshall Hall and Johannes Müller.

The history of science proves that unconnected, unsystematic, inaccurate observations are worth nothing. For untold ages men have had ample opportunities of studying the indications of the weather, and have felt the utmost desire to obtain a knowledge of what they portend. Yet it may fairly be said that nothing had been done to the purpose until combined and systematic observations were made in this country and America. The fact is, that popular notions do not rest upon experience or observation. They rest, with scarcely an exception, upon metaphysical theories. In dealing with uneducated persons, both of the lower and higher ranks, physicians find abundance of theories as to the nature and the origin of disease, and of suggestions as to its cure. The only thing which would be of value is what we can scarcely ever get—an accurate observation of what they see and feel. Every fallacy of popular medicine, every solemn medical imposture, is the ghost of some long defunct doctrine of the schools. Therefore it is that common experience is almost absolutely useless in practical arts. They, without exception, depend for their progress upon the advance of science—that is, upon methodical, continuous, and scrupulously accurate observations and experiments.

Many important advances in the practice of medicine have been gained by direct and intentional experiments instituted with a therapeutical object. Such was the Hunterian operation for aneurism, the process of skin-grafting, and subperiosteal operations; such was the administration of chloroform and the introduction of nitrite of amyl, chloral hydrate, and carbolic acid. Such direct experiments still go on, and among them deserve mention, for the skill and the untiring patience with which they were carried out, those investigations upon the action of various drugs on the secretion of bile for which we are indebted to Professor Rutherford and his coadjutors. Even apparently accidental discoveries were not made accidentally. Hundreds of country surgeons must have been familiar with the cow-pox, and have seen examples of the immunity it conferred from the more terrible variola, but he who discovered vaccination was no falsely-called practical man. He was a man of science, the friend of Hunter and of Cavendish, an anatomist and natural philosopher. The fruits of Tenner's discovery are spread over the whole earth. This humble village doctor has saved more lives than the most glorious conqueror destroyed, but his name is little honored, and the only monument to his memory has been banished from association with vulgar kings and skillful homicides to an obscure corner of the great city where his