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. 27, 1863.] Heller’s Archiv., 1846, and alluded to by Professor Taylor in his work on Poisons, p. 539. There were also strong points of general resemblance to the other cases of Mullen and Hardman, quoted by Professor Taylor at the same page, and recorded in Guy’s Hospital Reports for October, 1857. As matters progressed, I took the opportunity of pointing this out as delicately as I could to the Baron, and asked if he had any suspicions of foul play. He seemed at first almost amused by the suggestion; but upon further consultation was inclined to take a graver view of the matter. We went carefully through the cases in question, the Baron translating that of Dr. Mayerhofer for my benefit, as I was not a German scholar. At his suggestion, we determined to analyse the various excretions, &c., and an examination was accordingly instituted in the Baron’s laboratory. He was always very particular in keeping up the supply of medicine, and would never allow the bottles, &c., to be thrown away. There was therefore some remnant of every medicine that had been made up for her. These we tested carefully, as well as the excreta, &c., both for arsenic and for antimony, but without finding the slightest trace of either. The analysis was conducted by the Baron, who took the greatest interest in it. I could not, perhaps, have done it myself. Such matters have not come within my line of practice. In such a case I should certainly not trust to my own manipulations. I trusted to those of the Baron, because I knew him to be an expert practical chemist, and in the daily habit of such operations. My own share in them was limited to the observation of results, and their comparison with those pointed out by Professor Taylor. I did not take any special pains to ascertain the purity of the chemical tests employed or of their being in fact what they were assumed to be. That is to say, when a colourless liquid with all the apparent characteristics of nitric acid was taken from a bottle labelled “Nit. Ac.” I took for granted that nitric acid was being employed. Similarly, of course, with the other chemical agents. It never occurred to me to do otherwise. Nor did I take any especial precautions to identify the matters examined. Others might certainly have been substituted; but if so, it must have been done by the Baron himself. It was, perhaps, possible that he might have conducted his investigations, under such supervision as I then exercised, with fictitious tests, and it was quite so to substitute other matters and mislead me by subjecting them to a real analysis. That is to say, this would have been possible to be done by the Baron. No one else could, under the circumstances, have done it, or at least without his direct connivance. I had no ground for any suspicion of the kind, nor do I see any now. I think it most unwarrantable. Every circumstance that came under my notice goes equally to contravene such a supposition. The Baron was devotedly attached to his wife: he supplied her liberally with professional advice, as also with nurses, medicine, and every necessary; his care for her led him to precautions which, in their incidental results, must have inevitably exposed any attempt at the administration of poison. During the severer period of the disorder, he had no opportunity of attempting such a crime, as he universally insisted on both food and medicine being both prepared and administered by the nurses; he himself rendered every assistance in the endeavour to detect any such attempt when its possibility had been suggested by myself; and lastly, Madame R** did not die, although the investigation had already removed all suspicion. I think such an imputation wholly unwarranted and unwarrantable from any one circumstance of the case.

23rd.—Madame R**, nausea, vomiting, tendency to diarrhœa, profuse perspiration, and general debility. Pulse low, 100. Spirits depressed. Burning pain in stomach—abdomen tender on pressure. Tongue discoloured.

26th.—Madame R** slightly better—less nausea and pain.

30th.—Madame R**. Improvement continues.

2nd.—Madame R** improving.

6th.—Ditto.

9th.—Recurrence of symptoms on Saturday evening. Increased nausea, vomited matter yellow with bile. Pulse low, 105. Throat sore, and slight constriction. Tongue foul.

13th.—Symptoms slightly ameliorated. Treatment continued.

16th.—Ditto. Tongue slightly clearer. Pulse 100.

20th.—Improvement continued. Pulse slightly firmer.

23rd.—Ditto.

24th.—Special visit. Return of symptoms last night. Great increase of nausea and vomiting—very yellow with bile. Throat sore and tongue foul. Abdomen very tender on pressure. Slight diarrhœa. Tingling sensation in limbs.

27th.—Slight improvement.

30th.—Continued, but slight. Pulse firmer.

3rd.—Improvement continued, especially in throat. Perspiration still distressing. Less tingling in limbs.

6th.—Improvement continued. Pulse somewhat firmer, 110.

(10th to 20th.—Absent in Gloucestershire.)

20th.—A slight rally. Baron says attack shortly after last visit, but recovery for time more rapid.

24th.—Improvement continues, but less rapid. Pulse 110.

27th.—Recurrence yesterday. Vomiting, purging amounting to diarrhœa. Soreness and aphthous state of mouth and throat. Perspiration. Pain in abdomen. Complains of taste in mouth like lead. Pulse low, 115. Qy. antimony? Speak, Baron.

31st.—Analysis—satisfactory. Symptoms slightly abated.