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 CAP TAN and T HIOP HAN ATE -MET HYL: M ETH OD 9205, Issue 1, dated 1 5 Ma rch 2003 - Page 4 of 4 Based on the needs of the laboratory and the complexity of the samples to be analyzed, it may be necess ary to mak e other changes to the analysis parameters to get the best resolution of the compounds in the samples.

REFERENCES: [1] Jaycox LB, Andrews RN [2002]. Backup data report for Captan and Thiophanate-methyl on Dermal Patch method development, Cincinnati, OH: National Institute for Occupational Safety and Health, DAR T/NIO SH (un published, June). [2] NIOSH [1998]. Meth od 9201: Chlorinate d organonitrogen herbicides (derm al patc h). In: C assinelli ME, O’C onn or PF, ed s. NIOS H M anu al of Analytical M etho ds (N MA M), 4 th ed., 2 nd sup plem ent. Cinc innati, OH : National Ins titute for O ccu pation al Safety and Health, D HH S (N IOS H) P ubl 98 -119.

METHOD WRITTEN BY: Larry B. Jaycox, Ph.D. and Ronnee N. Andrews, NIOSH/DART

Table 1. Analyte Captan Thiophanate -m eth yl

Range 67.5-6220 :g/s am ple 62.0-6120 :g/s am ple

Estimated LOD 20.2 :g/s am ple 18.6 :g/s am ple

Precision (þ r) 0.0256 0.0229

Figure 1 This chromatogram shows results from a spiked patch sample that was extracted and analyzed by this method. The analyte quantities were: thiophanate-methyl - 200 µg/sample and captan- 50 µg/sample.

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition