Page:NIOSH Manual of Analytical Methods - 9111.pdf/1

 C6H5·CH2·CH(CH3)·NH·CH3

MW: 149.2

CAS: 537-46-2

METHOD: 9111, Issue 1

RTECS: SH4910000

EVALUATION: Partial

U.S. regulatory OELs OSHA or MSHA: None for surfaces Other published OELs and guidelines ACGIH, AIHA or NIOSH: None for surfaces States: Table 1

9111

Issue 1: 17 October 2011

PROPERTIES: White solid, MP 171 - 175 °C; VP 0.163 mm Hg @ 25 °C; pKa = 9.87 @ 25 °C; Water Sol. (1.33 g/100 mL @ 25 °C). Log P = 2.07 (octanolwater partition coefficient).

SYNONYMS: ( S) - N, α- D i m e t hy l b e n ze n e e t h a n a m i n e ; ( S) - ( + ) - N, α- D i m e t hy l p h e n e t hy l a m i n e : d- 1 - Ph e ny l - 2 methylaminopropane. Methedrine; Desoxyn; chalk; crank; crystal; glass; ice; meth, speed; upper. SAMPLING SAMPLER:

Wipe

SAMPLE AREA:

100 cm² or 1000 cm²

SHIPMENT:

Ship refrigerated preferably

SAMPLE STABILITY:

At least 7 days at 22 °C At least 30 days at <6 °C

FIELD BLANKS:

2 to 10 blanks per set MEASUREMENT ACCURACY

TECHNIQUE:

LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY-SIM mode. See Table 2.

ANALYTE:

Methamphetamine

DESORPTION:

0.1 M sulfuric acid

INJECTION VOLUME:

50 µL

MOBILE PHASE:

OVERALL PRECISION ( ACCURACY:

Not Determined ):

150 mm x 4.6 mm, 5 µm Zorbax Eclipse XDB C18 x or equivalent. Column temperature 40 °C.

GRADIENT:

100% A for one min, gradient to 100% B (9 min), hold 5 min, gradient to 100% A (2 min), hold 8 min. Flow rate is 0.50 mL/min

Not Determined Not Determined

A: 5/95 acetonitrile/water, 0.1% acetic acid B: 95/5 acetonitrile/water, 0.1% acetic acid

COLUMN:

RANGE STUDIED: Not Determined BIAS:

MEASUREMENT

CALIBRATION: Media spiked standards to cover the range (See Table 3) RANGE:

0.1 – 100 µg/sample

ESTIMATED LOD:

0.1 µg/sample

PRECISION : 0.067 [1] APPLICABILITY: For methamphetamine the range is approximately 0.1 to 100 µg/sample (sample = 100 cm²). INTERFERENCES: No chromatographic interferences detected. OTHER WIPE METHODS: NIOSH 9106 uses liquid-liquid extraction and gas chromatography/mass spectrometry (GC/MS) to measure multiple drugs [2]. NIOSH 9109 uses solid-phase extraction and GC/MS to measure multiple drugs [3].

NIOSH Manual of Analytical Methods (NMAM), Fifth Edition

Method rev. 1.1.1