Page:NIOSH Manual of Analytical Methods - 9109.pdf/23

 METHAMPHETAMINE. . . on Wipes by SPE: METHOD 9109, Issue 1, dated 17 October 2011 - Page 23 of 33

TABLE 11 (continued). Gas chromatographic retention times for heptafluorobutyryl and trimethylsilyl derivatives of selected drugs of abuse, precursors, and potential adulterants(1) GC Peak No.

Compound

Derivative Form(2)

41

Fentanyl (Sublimaze® etc.)

parent

42

Flunitrazepam (Rohypnol®, roofies)(10)

parent

43

Hydrocodone (Lortab® etc.)

HFB-

44

Hydrocodone (Lortab® etc.)

45 46

Notes (3)

Retention Time Minutes (4)

Relative Retention Time

Ions (Significant m/z) (7) 2’ (7)

3’ (7)

245

146 [60]

189 [33]

312

285 [95]

286 [90]

1.9588

495

438 [50]

298 [40]

1.6240

2.0946

371

356 [50]

234 [55]

20.93

1.6326

2.1056

299

242 [50]

243 [35]

19.85

1.5484

1.9970

308

267 [92]

358 [75]

Minor peak

20.98

1.6365

2.1107

414

429 [100]

234 [75]

O-TMS-

Pri.deriv.

21.21

1.6544

2.1338

357

300 [55]

342 [28]

parent

Major peak

15.24

1.1888

1.5332

180

182 [32]

209 [22]

Lidocaine

N-TMS-

Major peak

13.69

1.0679

1.3773

86

220 [75]

73 [45]

51

Lidocaine

parent

Major peak

15.28

1.1919

1.5372

86

58 [10]

91 [5]

52

LSD (MW-519, scanned only to 470)

HFB-

Pri.deriv.

24.61

1.9197

2.4759

417

221 [95]

418 [45]

53

MBDB

N-TMS-

Minor peak

14.30

1.1154

1.4386

144

73 [50]

135 [15]

54

MBDB

N-HFB-

Pri.deriv.

14.44

1.1264

1.4527

268

176 [75]

210 [50]

55

MDA

N-HFB-

Pri.deriv.

12.54

0.9782

1.2616

135

162 [55]

240 [12]

56

MDA

(5)

(6)

22.97

1.7917

2.3109

22.20

1.7317

2.2334

Minor peak

19.47

1.5187

TMS-

Minor peak

20.82

Hydrocodone (Lortab® etc.)

parent

Pri.deriv.

Hydromorphone (Dilaudid®)

O-HFB-O’-TMS-

Minor peak

47

Hydromorphone (Dilaudid®)

O,O’-bis-TMS-

48

Hydromorphone (Dilaudid®)

49

Ketamine (“special K”)(8)(10)

50

(8) (8)

1’

N-HFB-N-TMS-

OS artifact

12.88

1.0047

1.2958

312

73 [58]

135 [48]

57

(10)

MDEA

N-HFB-

Pri.deriv.

14.19

1.1069

1.4276

268

162 [60]

240 [50]

58

MDEA-D6 (I$)(9)

N-HFB-

Pri.deriv.

14.13

1.1022

1.4215

274

165 [46]

244 [35]

59

MDMA

N-HFB-

Pri.deriv.

13.81

1.0772

1.3893

254

162 [80]

135 [45]

60

Meperidine (Demerol® etc.)

parent

13.97

1.0897

1.4054

247

246 [55]

218 [50]

61

Mephentermine

N-HFB-

Pri.deriv.

10.38

0.8097

1.0443

268

210 [95]

62

Mescaline

N-HFB-

Pri.deriv.

14.68

1.1451

1.4769

181

194 [45]

63

Mescaline

N-HFB-N-TMS-

OS artifact

15.26

1.1903

1.5352

181

73 [35]

64

Methamphetamine

N-HFB-

Pri.deriv.

9.94

0.7754

1.0000

254

210 [35]

118 [22]

65

Methamphetamine-D5 (I$)(9)

N-HFB-

Pri.deriv.

9.86

0.7691

0.9920

258

213 [30]

92 [20]

66

(9)

Methamphetamine-D9 (I$)

N-HFB-

Pri.deriv.

9.84

0.7676

0.9899

261

213 [30]

123 [18]

67

(9)

Methamphetamine-D11 (I$)

N-HFB-

Pri.deriv.

9.84

0.7676

0.9899

260

213 [25]

126 [20]

68

Methamphetamine-D14 (I$)(9)

N-HFB-

Pri.deriv.

9.86

0.7691

0.9920

261

213 [30]

128 [20]

69

Methaqualone

parent

18.31

1.4282

1.8421

235

250 [30]

233 [28]

70

S-(-)-Methcathinone (“Cat”)

N-HFB-

Pri.deriv.

10.55

0.8229

1.0614

254

210 [35]

105 [100]

71

4-Methoxyamphetamine

N-HFB-

Pri.deriv.

11.40

0.8892

1.1469

121

148 [40]

240 [10]

72

4-Methoxyamphetamine

N-HFB-N-TMS-

OS artifact

11.87

0.9259

1.1942

312

121 [100]

73 [100]

73

cis-(±)-4-Methylaminorex (“U4Euh”)

N,N’-bis-HFB-

Minor peak

13.78

1.0749

1.3863

399

169 [70]

160 [75]

74

cis-(±)-4-Methylaminorex (“U4Euh”)

N-HFB-N’-TMS-

Pri.deriv.

16.78

1.3089

1.6881

275

160 [60]

117 [30]

75

(-)-N-Methylephedrine

O-TMS-

Pri.deriv.

9.66

0.7535

0.9718

72

73 [13]

163 [5]

76

(+)-N-Methylephedrine

O-TMS-

Pri.deriv.

9.71

0.7574

0.9769

72

73 [13]

163 [5]

77

N-Methylphenethylamine (I$)

N-HFB-

Pri.deriv.

9.54

0.7441

0.9598

240

104 [100]

169 [40]

78

Methylphenidate (Ritalin®)

N-HFB-

Pri.deriv.

15.38

1.1997

1.5473

280

281 [10]

(10)

(12) (12) (9)

179 [30]

Table 11 continued

NIOSH Manual of Analytical Methods (NMAM), Fifth Edition

Method rev. 1.1.1