Page:NIOSH Manual of Analytical Methods - 9109.pdf/22

 METHAMPHETAMINE. . . on Wipes by SPE: METHOD 9109, Issue 1, dated 17 October 2011 - Page 22 of 33

TABLE 11. Gas chromatographic retention times for heptafluorobutyryl and trimethylsilyl derivatives of selected drugs of abuse, precursors, and potential adulterants(1) GC Peak No. Compound

Derivative Form(2)

Notes(3)

Retention Time Minutes(4)

Relative Retention Time (5)

Ions (Significant m/z)(7) 1’

(6)

2’(7)

3’(7)

1

Acetaminophen(8)

N,N’- bis-TMS-

Pri.deriv.

12.30

0.9594

1.2374

206

280 [90]

295 [70]

2

Acetaminophen

N-HFB-N’-TMS-

Minor peak

10.37

0.8089

1.0433

330

404 [80]

419 [30]

3

Aminorex

N,N’- bis-HFB-

Major peak

14.12

1.1014

1.4205

385

342 [30]

169 [40]

4

Aminorex

N-HFB-N’-TMS-

Major peak

16.59

1.2941

1.6690

261

146 [48]

128 [45]

5

Amphetamine

N-HFB-

Pri.deriv.

8.54

0.6661

0.8592

240

118 [70]

169 [20]

6

Amphetamine

N-HFB-N-TMS-

OS artifact

9.21

0.7184

0.9266

312

91 [50]

313 [10]

7

(9)

Amphetamine-D5, ring labeled (I$)

N-HFB-

Pri.deriv.

8.47

0.6607

0.8521

240

123 [85]

96 [55]

8

(9)

Amphetamine-D5,ring labeled (I$)

N-HFB-N-TMS-

OS artifact

9.17

0.7153

0.9225

312

96 [45]

73 [95]

9

Amphetamine-D6 (I$)(9)

N-HFB-

Pri.deriv.

8.45

0.6591

0.8501

244

123 [70]

93 [45]

10

Amphetamine-D6 (I$)

N-HFB-N-TMS-

OS artifact

9.14

0.7129

0.9195

316

93 [40]

73 [75]

11

Amphetamine-D8 (I$)

N-HFB-

Pri.deriv.

8.46

0.6599

0.8511

243

126 [75]

96 [40]

12

Amphetamine-D8 (I$)(9)

N-HFB-N-TMS-

OS artifact

9.16

0.7145

0.9215

315

96 [25]

73 [55]

13

Amphetamine-D11 (I$)

N-HFB-

Pri.deriv.

8.46

0.6599

0.8511

244

128 [70]

98 [45]

14

Amphetamine-D11 (I$)

N-HFB-N-TMS-

OS artifact

9.14

0.7129

0.9195

316

98 [60]

73 [70]

15

Atropine(8)

O-TMS-

Pri.deriv.

18.86

1.4711

1.8974

124

361 [9]

82 [17]

16

BDB

N-HFB-

Pri.deriv.

13.35

1.0413

1.3431

135

176 [50]

254 [12]

17

BDB

N-HFB-N-TMS-

OS artifact

13.65

1.0647

1.3732

326

135 [60]

73 [90]

18

Benzoyl ecgonine

O-TMS-

19.18

1.4961

1.9296

82

240 [45]

361 [25]

19

Benzyl piperazine(10) (“Legal XTC”)

N-HFB-

Pri.deriv.

13.73

1.0710

1.3813

91

372 [30]

281 [30]

20

4-Bromo-2,5-DMPEA (Nexus)

N-HFB-

Pri.deriv.

15.79

1.2317

1.5885

242

244 [98]

229 [75]

21

4-Bromo-2,5-DMPEA (Nexus)

N-HFB-N-TMS-

OS artifact

16.22

1.2652

1.6318

229

231 [98]

298 [85]

22

Bupropion (Wellbutrin®, Zyban®)

parent

12.15

0.9477

1.2223

44

100 [45]

111 [20]

23

Caffeine

parent

14.89

1.1615

1.4980

194

109 [45]

67 [45]

24

S-(-)-Cathinone (from Khat plant)

N-HFB-

Pri.deriv.

10.21

0.7964

1.0272

105

77 [45]

240 [15]

25

S-(-)-Cathinone (from Khat plant)

N-HFB-N-TMS-

OS artifact

10.89

0.8495

1.0956

105

312 [68]

77 [55]

26

Chlorpheniramine

parent

16.74

1.3058

1.6841

203

205 [32]

167 [22]

27

Cocaine

parent

18.65

1.4548

1.8763

82

182 [90]

303 [20]

28

Codeine

O-HFB-

Minor peak

19.59

1.5281

1.9708

282

283 [20]

29

Codeine

O-TMS-

Pri.deriv.

20.72

1.6162

2.0845

371

343 [25]

234 [55]

30

Dextromethorphan

parent

18.10

1.4119

1.8209

271

270 [62]

214 [40]

31

Diazepam (Valium® etc.)

parent

20.80

1.6225

2.0926

256

283 [90]

284 [75]

32

Dibromooctafluorobiphenyl (I$)(9)

parent

12.82

1.0000

1.2897

296

456 [100]

454 [50]

33

N,N-Dimethyltryptamine (DMT)

N-HFB-

Pri.deriv.

13.00

1.0140

1.3078

58

129 [15]

42 [15]

34

N,N-Dimethyltryptamine (DMT)

N-TMS-

Minor peak

15.02

1.1716

1.5111

58

73 [12]

202 [10]

35

Ecgonine, methyl ester

O-TMS-

11.72

0.9142

1.1791

82

96 [75]

83 [75]

36

Ephedrine

37 38

(8)

(9) (9)

(9) (9)

(11) (11)

(8)

(8)

(8)

N-HFB-O-TMS-

Pri.deriv.

11.40

0.8892

1.1469

179

254 [17]

327 [10]

1S,2R(+)-Ephedrine-D3 (I$)

N-HFB-O-TMS-

Pri.deriv.

11.36

0.8861

1.1429

179

257 [20]

330 [10]

N-Ethyl amphetamine

N-HFB-

Pri.deriv.

10.33

0.8058

1.0392

268

240 [35]

118 [15]

39

Fenfluramine

N-HFB-

Pri.deriv.

10.12

0.7894

1.0181

268

240 [35]

159 [22]

40

Fenfluramine-D10 (I$)

N-HFB-

Pri.deriv.

10.01

0.7808

1.0070

277

245 [35]

160 [15]

(9)

(8)

Method rev. 1.1.1

(9)

Table 11 continued NIOSH Manual of Analytical Methods (NMAM), Fifth Edition