Page:NIOSH Manual of Analytical Methods - 9109.pdf/19

 METHAMPHETAMINE. . . on Wipes by SPE: METHOD 9109, Issue 1, dated 17 October 2011 - Page 19 of 33

Table 9b. Recommended best application of internal standards(1) Recommended Alternate Non-deuterated Internal Standards(3)

Recommended Deuterated Internal Standards Target Analyte

Amphetamine-D11(2)

Methamphetamine-D14(2)

Amphetamine

X

X

X

Cocaine

X

X

X

Ephedrine

X

X

X

MDEA

MDEA-D6(1) Phencyclidine-D5

N-Methylphenethylamine

X

X

MDMA

X

X

X

Methamphetamine

X

X

X

Phencyclidine

X

X

Phentermine

X

X

X

(±)-Norephedrine

X

X

X

Pseudoephedrine

X

X

X

(4)

N-Propylamphetamine(1)

X

X

(1)	 N-Propylamphetamine and MDEA-D6 are only applicable to MDEA and other hindered amines (e.g., fenfluramine and MBDB) due to similar steric hindrance at the nitrogen (N-ethyl or N-propyl substitution) which affects derivatization efficiency. (2)	 The alternate deuterated compounds listed in part A above may be used. Avoid ring-labeled amphetamine-D5 (CAS 65538-33-2) since the primary (quantification) ion is the same as for amphetamine and GC peaks overlap significantly. Also avoid methamphetamine-D5 (CAS 60124-88-1) since GC peaks significantly overlap. (3)	 The listed non-deuterated compounds are acceptable as internal standards for the listed target analytes for the applicable ranges and limits of detection listed in Tables 8a and 8b respectively. Non-deuterated internal standards might not be permissible. Consult regulations of agency having legal jurisdiction. (4)	 (±)-Norephedrine is the same as (±)-phenylpropanolamine.

NIOSH Manual of Analytical Methods (NMAM), Fifth Edition

Method rev. 1.1.1