Page:NIOSH Manual of Analytical Methods - 9109.pdf/17

 METHAMPHETAMINE. . . on Wipes by SPE: METHOD 9109, Issue 1, dated 17 October 2011 - Page 17 of 33

Table 8a. Precision and accuracy in scan mode for cotton gauze(1) Bias

Overall

Compound

Internal Standard(2)

Range(3) µg/sample

Accuracy

Precision

(D)-Amphetamine

D11-Amp

0.1-30

8.1

0.0412

-0.0054

-0.0386 to +0.0428

D14-Met

0.1-30

10.3

0.0472

-0.0227

-0.0844 to +0.0199

NMPhen

0.1-30

13.2

0.0662

-0.0120

-0.0931 to +0.0290

D11-Amp

1.0-30

15.8

0.0469

+0.0810

+0.0416 to +0.1375

D14-Met

3-30

13.3

0.0422

+0.0631

+0.0003 to +0.1294

NMPhen

0.3-30

20.2

0.0729

+0.0823

-0.0092 to +0.1359

D11-Amp

0.1-30

9.8

0.0499

-0.0052

-0.0608 to +0.0262

D14-Met

0.1-30

9.2

0.0397

-0.0266

-0.0463 to +0.0221

NMPhen

0.1-30

11.2

0.0493

-0.0284

-0.0775 to +0.0302

MDEA

N-PAmp

0.3-29

12.4

0.0618

+0.0127

-0.0475 to +0.0869

MDMA

D11-Amp

0.1-27

14.3

0.0568

+0.0497

+0.0104 to +0.1197

D14-Met

0.1-27

13.1

0.0558

+0.0389

-0.0189 to +0.0978

NMPhen

0.3-27

11.9

0.0605

+0.0007

-0.0570 to +0.0360

D11-Amp

0.1-10

9.2

0.0395

+0.0270

-0.0289 to +0.0923

D14-Met

0.1-30

5.9

0.0302

+0.0015

-0.0440 to +0.0592

NMPhen

0.3-30

6.9

0.0334

+0.0113

-0.0534 to +0.0448

D11-Amp

0.3-30

17.2

0.0639

+0.0670

+0.0059 to +0.1222

D14-Met

0.3-30

15.9

0.0648

+0.0521

-0.0386 to +0.1039

NMPhen

0.3-30

16.0

0.0638

+0.0547

-0.0474 to +0.0886

D11-Amp

0.1-30

10.1

0.0444

+0.0261

-0.0067 to +0.0912

D14-Met

0.1-30

10.4

0.0527

+0.0041

-0.0600 to +0.0674

NMPhen

1.0-30

8.2

0.0400

+0.0121

-0.0378 to +0.0407

D11-Amp

0.1-30

12.2

0.0571

+0.0241

+0.0500 to +0.0610

D14-Met

0.1-30

12.5

0.0638

-0.0005

-0.0674 to +0.0708

NMPhen

0.1-30

13.3

0.0675

+0.0036

-0.0533 to +0.0476

D11-Amp

0.1-30

10.0

0.0507

-0.0059

-0.0530 to +0.0441

D14-Met

0.1-30

12.3

0.0507

-0.0392

-0.0737 to +0.0301

NMPhen

1.0-30

15.6

0.0716

-0.0350

-0.0813 to +0.0617

Cocaine

(L)-Ephedrine

(D)-Methamphetamine

Phencyclidine

Phentermine

(±)-Norephedrine(4)

Pseudoephedrine

Average

Range

(1)	 Backup Data Report [2]. Values are for the heptafluorobutyryl and mixed heptafluorobutyryl-trimethylsilyl derivatives and analysis by GC-MS in scan mode. Each sample consisted of a pair of 3” x 3” 12-ply cotton gauze pads. There were 6 replicate samples per concentration level and six concentration levels evaluated from approximately 0.1 to 30 µg/sample. (2)	 Internal Standards Deuterated: Non-deuterated: D11-Amp = Amphetamine-D11 NMPhen = N-Methyl phenethylamine D14-Met = Methamphetamine-D14	 N-PAmp = N-Propyl amphetamine (3)	 Range used for calculation of precision, accuracy, and bias. The entire range studied for all analytes was approximately 0.1 to 30 µg/sample (1xLOQ to 300xLOQ). (4)	 (±)-Norephedrine = (±)-phenylpropanolamine.

NIOSH Manual of Analytical Methods (NMAM), Fifth Edition

Method rev. 1.1.1