Page:NIOSH Manual of Analytical Methods - 9109.pdf/12

 METHAMPHETAMINE. . . on Wipes by SPE: METHOD 9109, Issue 1, dated 17 October 2011 - Page 12 of 33

Table 3. Physical properties of analytes(1) Compound (alphabetically)

CAS

m.p. (°C)

Vapor Pressure (mm Hg)

pKa(4)

Log P(5)

Solubility in Water, g/100mL

(DL)-Amphetamine

300-62-9

—

—

10.1 @ 20 °C

1.76

2.8 @ 25 °C

(D)-Amphetamine

51-64-9

<25

—

9.9(6)

1.76

—

(D)-Amphetamine sulfate

51-63-8

>300

—

—

6.81

—

(L)-Amphetamine

156-34-3

—

10.1 @ 20 °C

1.76

2.8 @ 25 °C

Caffeine

58-08-2

238

15 @ 89 °C

10.4 @ 40 °C

-0.07

2.16 @ 25 °C

(DL)-Ephedrine

90-81-3

76.5

—

—

0.68

—

(L)-Ephedrine

299-42-3

34

0.00083 @ 25 °C

10.3 @ 0 °C

1.13

63.6 @ 30 °C

(L)-Ephedrine HCl

50-98-6

218

2.04E-10 @ 25 °C

pH 5.9 @ 1/200 dil.(3)

-2.45

25(6)

MDEA

82801-81-8 —

—

—

—

—

MDMA HCl

42542-10-9 148-149(2) —

—

—

—

(D)-Methamphetamine

537-46-2

—

9.87 @ 25 °C

2.07

1.33 @ 25 °C

(D)-Methamphetamine HCl

51-57-0

170-175(2) —

—

—

—

Phencyclidine

77-10-1

46.5

8.29

4.69

—

Phencyclidine HCl

956-90-1

233-235(2) —

—

—

—

Phentermine

122-09-8

—

0.0961 @ 25°C

—

1.90

1.86 @ 25 °C

Phentermine HCl

1197-21-3

198(2)

—

—

—

—

(±) Phenylpropanolamine

14838-15-4 —

0.000867 @ 25 °C 9.44 @ 20 °C

0.67

14.9 @ 25 °C

—

—

-2.75

—

—

—

—

—

0.201 @ 25 °C

0.163 @ 25 °C

—

(6)

(±) Phenylpropanolamine HCl 154-41-6

194

(L)-Norephedrine

492-41-1

51-53

1S,2S (+)-Norephedrine

36393-56-3 77.5-78

0.000867 @ 25 °C 9.44 @ 20 °C

0.83

14.9 @ 25 °C

1S,2S (+)-Norephedrine HCl

492-39-7

—

—

pH 5.9-6.1 in aq. soln.(3)

0.22

2 @ 25 °C

(D)-Pseudoephedrine

90-82-4

119

0.00083 @ 25 °C

10.3 @ 0 °C

0.89

10.6 @ 25 °C

(D)-Pseudoephedrine HCl

345-78-8

181-182(2) —

pH 5.9 @ 1/200 dil.(3)

—

—

(1)	(2)	(3)	(4)	(5)	(6)

(3)

Handbook of Physical Properties of Organic Chemicals unless otherwise noted [17]. Merck Index [13]. Sigma-Aldrich MSDS [15]. Negative log of the acid dissociation constant for the amine in aqueous solution. Log P = octanol-water partition coefficient. Temperature not given in source.

Method rev. 1.1.1

NIOSH Manual of Analytical Methods (NMAM), Fifth Edition