Page:NIOSH Manual of Analytical Methods - 9109.pdf/10

 METHAMPHETAMINE. . . on Wipes by SPE: METHOD 9109, Issue 1, dated 17 October 2011 - Page 10 of 33

Table 1. Formula and registry numbers of analytes MW(1) (Daltons) Compound (alphabetically)

Free base

HCl salt

Hemisulfate salt

Structural Formula As free base

(DL)-Amphetamine

135.21

171.67

184.25

C6H5·CH2·CH(CH3)·NH2

(D)-Amphetamine(7)

135.21

171.67

184.25

C6H5·CH2·CH(CH3)·NH2

(L)-Amphetamine

135.21

171.67

184.25

Caffeine

194.19

(DL)-Ephedrine

165.24

201.70

(L)-Ephedrine(8)

165.24

(D)-Ephedrine

CAS #(2)

RTECS(6) SH9450000 SI1750000 SI1400000

C6H5·CH2·CH(CH3)·NH2

300-62-9 60-13-9(5) 51-64-9(3) 51-63-8(5) 156-34-3(3)

(CH3)3·[C5HN4O2]

58-08-2

EV6475000

214.28

C6H5·CH(OH)·CH(CH3)·NH·CH3

201.70

214.28

C6H5·CH(OH)·CH(CH3)NH·CH3

90-81-3 134-71-4(4) 299-42-3(3) 50-98-6(4) 134-72-5(5)

165.24

201.70

214.28

C6H5·CH(OH)·CH(CH3)NH·CH3

(±)-MDEA

207.27

243.73

CH2O2C6H3·CH2·CH(CH3)NH·C2H5

(±)-MDMA

193.24

229.71

CH2O2C6H3·CH2·CH(CH3)·NH·CH3

(+)-MDMA(7) (DL)-Methamphetamine

193.24 149.24

229.71 185.70

198.28

CH2O2C6H3·CH2·CH(CH3)·NH·CH3 C6H5·CH2·CH(CH3)·NH·CH3

(D)-Methamphetamine(7)

149.24

185.70

198.28

C6H5·CH2·CH(CH3)·NH·CH3

(L)-Methamphetamine

149.24

185.70

198.28

C6H5·CH2·CH(CH3)·NH·CH3

Phencyclidine

243.39

279.85

C6H5·C[C5H10]·N[C5H10]

Phentermine

149.24

185.70

C6H5·CH2·C(CH3)2·NH2

(DL)-Norephedrine

151.21

187.67

200.25

C6H5·CH(OH)·CH(CH3)·NH2

1R,2S (-)-Norephedrine

151.21

187.67

200.25

1S,2R (+)-Norephedrine

151.21

187.67

1S,2S (+)-Norephedrine

151.21

(D)-Pseudoephedrine(8,9) (L)-Pseudoephedrine(10)

(3)

(3)

SH9050000

(3)

321-98-2(3) 24221-86-1(4) 82801-81-8(3) 116261-63-2(4) 42542-10-9(3) 92279-84-0(4) 64057-70-1(4) 4846-07-5(3)

KB0700000 KB1750000 KB2625000 KB0600000 KB1925000

SH5700000 SH5700000

537-46-2(3) 51-57-0(4) 33817-09-3(3)

SH4910000 SH5455000 SH4905000 TN2272600 TN2272600 SH4950000

C6H5·CH(OH)·CH(CH3)·NH2

77-10-1(3) 956-90-1(4) 122-09-8(3) 1197-21-3(4) 14838-15-4(3) 154-41-6(4) 492-41-1(3)

200.25

C6H5·CH(OH)·CH(CH3)·NH2

37577-28-9(3)

187.67

200.25

C6H5·CH(OH)·CH(CH3)·NH2

165.24

201.70

214.28

C6H5·CH(OH)·CH(CH3)·NHCH3

165.24

201.70

214.28

C6H5·CH(OH)·CH(CH3)·NH·CH3

36393-56-3 2153-98-2(4) 492-39-7(4) 90-82-4(3) 345-78-8(4) 321-97-1(3)

RC2625000 DN4200000 RC2275000

RC9275000

UL5800000 UL5950000

(1)	 Molecular weights are calculated from the empirical formula using the 1987 IUPAC Atomic Weights of the Elements, Merck Index [10]. The molecular weight of the hemisulfate is ½ the weight of the 2:1 sulfate salt (2 moles amine + 1 mole H2SO4). (2)	 CAS from various sources: Merck Index [13], NIOSH RTECS [14], MSDS sheets from Sigma/Aldrich [15], Cerilliant [16], and other sources [17]. (3)	 Free base form. (4)	 Hydrochloride salt. (5)	 2:1 Sulfate salt (2 moles amine + 1 mole H2SO4. (6)	 RTECS = NIOSH Registry of Toxic Effects of Chemical Substances [14]. (7)	 More active isomer. (8)	 Naturally occurring isomer. (9)	 The D form of pseudoephedrine is a decongestant. (10)	 The L form of pseudoephedrine is a bronchodilator. Dehydroxylation forms the less active L-methamphetamine.

Method rev. 1.1.1

NIOSH Manual of Analytical Methods (NMAM), Fifth Edition