Page:NIOSH Manual of Analytical Methods - 9106.pdf/17

 METHAMPHETAMINE. . .on Wipes by Liquid-Liquid Extraction: METHOD 9106, Issue 1, dated 17 October 2011 - Page 17 of 31

Table 8a. Precision and accuracy in scan mode.(1) Compound (D)-Amphetamine

Caffeine

(L)-Ephedrine MDEA MDMA

(D)-Methamphetamine

Phencyclidine

Phentermine (±)-Norephedrine(4) Pseudoephedrine

Internal Standard(2)

Range(3) µg/sample Accuracy

D11-Amp D14-Met NMPhen D11-Amp D14-Met NMPhen D11-Amp D14-Met NMPhen N-PAmp D11-Amp D14-Met NMPhen D11-Amp D14-Met NMPhen D11-Amp D14-Met NMPhen D11-Amp D14-Met NMPhen

0.1-30 0.1-30 0.1-30 1.0-30 1.0-30 1.0-30 0.1-10 0.3-10 0.3-30 0.3-29 0.3-27 0.3-27 0.3-27 0.1-30 0.1-30 0.1-10(5) 0.1-10 0.3-3 0.3-10 0.1-30 0.1-30 0.1-30

D11-Amp D11-Amp D14-Met NMPhen

1-30 0.3-30 0.3-30 0.3-30

17.1 13.7 12.5 20.0 12.5 15.6 15.4 17.8 15.0 16.6 20.2 16.6 22.0 14.7 12.5 14.9 18.2 13.4 16.8 15.2 10.7 9.6 6.5 17.2 14.9 18.7

Bias

Overall Precision

Average

Range

0.0670 0.0610 0.0559 0.0708 0.0636 0.0796 0.0627 0.0674 0.0707 0.0817 0.0778 0.0652 0.0722 0.0631 0.0546 0.0503 0.0690 0.0465 0.0609 0.0486 0.0509 0.0420 0.0328 0.0571 0.0649 0.0488

-0.0613 +0.0338 -0.0310 -0.0832 -0.0014 -0.0040 +0.0510 +0.0666 +0.0293 -0.0224 -0.0739 +0.0589 -0.1017 -0.0435 -0.0348 -0.0665 -0.0683 -0.0577 -0.0682 -0.0720 +0.0190 -0.0269 +0.0061 -0.0783 -0.0422 -0.1068

-0.1048 - -0.0170 -0.0151 - +0.1056 -0.0651 - +0.0177 - 0.1476 - -0.0542 - 0.0274 - +0.0381 -0.0789 - +0.1321 -0.0148 - +0.1128 +0.0261 - +0.1660 -0.0259 - +0.0973 -0.0656 - +0.0657 -0.1011 - -0.0489 -0.0947 - +0.0036 -0.1486 - -0.0315 -0.0657 - -0.0060 -0.1144 - +0.0188 -0.1179 - +0.0110 -0.1257 - -0.0136 -0.0662 - -0.0493 -0.1137 - +0.0091 -0.1010 - +0.0291 -0.0395 - +0.0671 -0.0612 - +0.0340 -0.0070 - +0.0248 -0.1273 - -0.0560 -0.0888 - +0.0395 -0.1505 - -0.0422

(1)	 Backup Data Report [1]. Values are for chlorodifluoroacetyl derivatives and analysis by GC-MS in scan mode. Each sample consisted of a pair of 3” x 3” 12-ply cotton gauze pads. There were 6 replicate samples per concentration level and six concentration levels evaluated from approximately 0.1 to 30 µg/sample. (2)	 Internal Standards	  Deuterated: Non-deuterated: D11-Amp = Amphetamine-D11 NMPhen = N-Methyl phenethylamine

D14-Met = Methamphetamine-D14

N-PAmp = N-Propyl amphetamine

(3)	 Range used for calculation of precision, accuracy, and bias. The entire range studied for all analytes was approximately 0.1 to 30 µg/sample (1xLOQ to 300xLOQ). (4)	 (±)-Norephedrine = (±)-phenylpropanolamine. (5)	 One or more higher level concentrations were omitted from the computations due to inlier CVs (<0.0200.)

NIOSH Manual of Analytical Methods (NMAM), Fifth Edition

Method rev. 1.1.1