Page:NIOSH Manual of Analytical Methods - 8317.pdf/6

 ANILINE and @-TO LUIDIN E in urine: MET HO D 831 7, Issue 1, dated 15 M arch 200 3 - Page 6 o f 6 and 16 ng/mL, aniline and @-toluidine. The precision and recovery data reported on page 8317-1 was an average of these levels, a nd re porte d be low in a m ore d etailed resu lts table. In add ition, blind field splits were also use d to chara cterize the precision of the m etho d. RECOVERY [4]

aniline aniline aniline acetanilide @-toluidine @-toluidine @-toluidine N-acetyltoluidine

PRECISION ( þ r) [4] aniline aniline aniline acetanilide @-toluidine @-toluidine @-toluidine N-acetyltoluidine

109 97 93 96 101 93 86 83

% % % % % % % %

0.26 0.14 0.12 0.16 0.32 0.17 0.14 0.17

@ @ @ @ @ @ @ @

@ @ @ @ @ @ @ @

6.9 ng/m L 18 ng/m L 77 ng/mL 19 ng/m L 4.2 ng/m L 20 ng/m L 102 ng/m L 16 ng/m L

6.9 ng/m L 18 ng/m L 77 ng/mL 19 ng/m L 4.2 ng/m L 20 ng/m L 102 ng/m L 16 ng/m L

Du plicate blind splits Pairs of duplicates 43 Range (ng/mL) 10 - 350 Average Relative Standard Deviation 23 %

REFERENCES: [1]

[2] [3] [4]

[5]

[6]

[7]

[8]

ACG IH [1986]. Am erican Con ference of G overnm ental Industrial Hygienists: Biological Exposu re Indice s, 5 th ed, pp. BE151-BE153. Cincinnati, OH: Am erican Conference of Governmental Industrial Hygienists. Cheever KL, Richards DE, Plo tnik HB [1980]. Meta bolism of o rtho-, m eta -, and para-T oluidine in the A dult M ale R at, Toxicol. Appl. Pharm aco l. 56:361-369. El-Bayoum y K, Donahue JM, H echt SS, H offm ann D [1986]. Identification and Qua ntitative Determination of Aniline and Toluidines in Hum an Urine. Cancer Res 46:6064-6067. Brown K K, Teas s AW, Simon S, W ard EM (1995). A Biological Monitoring Method for @-Toluidine and Aniline in Urine Using High Performance Liquid Chromatography with Electrochemical De tection, App l. Occup. Environ. H yg., 10(6):557-565. Teass AW, DeBord DG, Brown KK, Cheever KL, Stettler LE, Savage RE, W eigel W W, Dankovic D, W ard E [1993]. Biological Monitoring for Occupational Exposures to @-Toluidine and Aniline, Int. Arc h. O ccu p. En viron. H ealth, 65:S115-S118. Stettler LE, Savage RE, Brown KK, Cheever KL, W eigel W W, DeBord DG, Teass AW , Dankovic D, W ard EM [1992]. Biological Monitoring for Occupational Exposures to @-Toluidine and Aniline, Scand J. W ork Environ. H ealth; 18: Supple 2: 78-81. W ard EM, Sabbioni G, DeBord DG, Teass AW, Brown KK, Talaska GG, Roberts DR, Ruder AM, Streicher RP [1996]. Monitoring of Arom atic Am ine Expo sures in W ork ers at a C hem ical Plant W ith a Kn own Bladder C anc er Exce ss, J. Nat. Can cer Inst., 88(15): 1046-1052. Ru der A M, W ard E M, R obe rts D R, T eas s AW, Brow n KK , Fingerhu t MA , Stettler L E [19 92]. Re spo nse of the National Ins titute for O ccu pation al Safety and Health to an O ccu pation al He alth Risk from exposure to @-Toluidine and Aniline, S can d J. W ork Environ. H ealth, 18: Supple 2: 82-84.

METHOD DEVELOPED BY: Kenneth K. Brown, Ph.D., NIOSH/ DART

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition