Page:NIOSH Manual of Analytical Methods - 8303.pdf/4

 PENTACHLOROPHENOL in urine: METHOD 8303, Issue 2, dated 15 August 1994 - Page 4 of 4 EVALUATION OF METHOD: The recovery of PCP from spiked urine samples was 93 to 96% for specimens containing 5 to 1000 µg PCP/L urine. The recovery of PCP from frozen urine samples spiked with 100 ng PCP/L urine and stored up to 36 days ranged from 85 to 91%.

REFERENCES: [1] NIOSH Manual of Analytical Methods, P&CAM 358 (unpublished, 1983). [2] Bruan, W.H., Blau, G.E., Chensweth, M.B. The Metabolism/Pharmacokinetics of Pentachlorophenol in Man, and a Comparison with the Rat and Monkey, Toxicology Research Laboratory, Dow Chemical, USA, Midland, MI 48640. [3] NIOSH Manual of Analytical Methods, 2nd ed., V. 1, P&CAM 230, U.S. Department of Health, Education, and Welfare, Publ. (NIOSH) 77-157-A (1977). [4] Diazald, Cat. No. 02800-0, Aldrich Chemical Co., Inc., Milwaukee, WI. [5] Tietz, N.W. Fundamentals of Clinical Chemistry, 2nd ed., 994-999, W.B. Saunders Co., Philadelphia, PA (1976). [6] Edgerton, T.R., Moseman, R.F. Determination of Pentachlorophenol in Urine: The Importance of Hydrolysis, J. Agric. Food Chem., 27, 197-199 (1979). [7] Dougherty, R.C. Human Exposure to Pentachlorophenol, Dept. of Chemistry, Florida State University, Tallahassee, FL. [8] Klemmer, H.W., Wang, L., Sato, M.M., Reichert, E.L., Korsak, R.J. and Rashad, M.N. Clinical Findings in Workers Exposed to Pentachlorophenol, Arch. Environm. Contam. Toxicol., 9, 715-725 (1980). [9] Williams, P.L. Pentachlorophenol, an Assessment of the Occupational Hazard, Am. Ind. Hyg. Assoc. J., 43, 799-810 (1982). [10] Lauwery, R.R. Industrial Chemical Exposure, Guidelines for Biological Monitoring , 143, Biomedical Publications, Davis, CA (1983). [11] 1993-1994 Threshold Limit Values and Biological Exposure Indices, American Conference of Governmental Industrial Hygienists, Cincinnati, OH (1993).

METHOD REVISED BY: Anthony W. Smallwood, William P. Tolos, and Karl E. DeBord, NIOSH/DBBS; and Robert Kurimo, NIOSH/DPSE.

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94