Page:NIOSH Manual of Analytical Methods - 5516.pdf/1



CH$3$C$6$H$3$(NH$2$)$2$

MW: 122.17

CAS: 2,4-: 95-80-7

CAS: 2,6-: 823-40-5

RTECS: 2,4-: XS9625000

RTECS: 2,6-: XS9750000

METHOD: 5516, Issue 2

EVALUATION: PARTIAL

Issue 1: 15 May 1989

Issue 2: 15 August 1994

OSHA:	 no PEL

NIOSH:	2,4-: lowest feasible; carcinogen

ACGIH:	 no TLV

PROPERTIES:	 2,4-: solid; MP 99 °C

2,6-: solid; MP 106 °C

2,4-: 4-methyl-1,3-benzenediamine; 2,4-diaminotoluene

2,6-: 2-methyl-1,3-benzenediamine; 2,6-diaminotoluene

SAMPLING

MEASUREMENT

isocyanates [2], determines 2,4- and 2,6-toluenediamine in air in the presence of isocyanates. Samples from polyurethane foam plants were analyzed simultaneously for 2,4- and 2,6-toluenediamine and 2,4- and 2,6-toluene diisocyanate [1].
 * The working range is 3 to 30 μg/m$18$ for a 100-L air sample. This method, based on that of Warwick et al. for


 * -Phenylenediamine interferes in the determination of 2,4-toluenediamine.

and HPLC with electrochemical detection. Other methods are: (a) absorb on Tenax GC, desorb in toluene, GC [4]; (b) absorb on silica gel, desorb in 2-butanone, GC [5]; (c) sample in aqueous acid, work up, GC of free amines [6] or bis(heptafluoro­ butyryl)amides [7,8]; (d) sample in ethanolic KOH, workup, LC of free amine [9,10] or GC of bis(pentafluoropropionyl) amides [11]; (e) sample with sulfuric acid-coated filter, work up, GC of bis(heptafluorobutyryl)amides [12]. Some of these methods [3,9—11] can be used for the simultaneous determination of toluenediamines and toluene diisocyanates.
 * Holdren et al. [3] reported a similar method using N-(4-nitrobenzyl)propylamine in toluene for sampling