Page:NIOSH Manual of Analytical Methods - 5512.pdf/1

 PENTACHLOROPHENOL

C6Cl5OH

MW: 266.35

METHOD: 5512, Issue 2

CAS: 87-86-5

5512

RTECS: SM6300000

EVALUATION: FULL

OSHA : 0.5 mg/m 3 (skin) NIOSH: 0.5 mg/m 3 (skin); Group I Pesticide ACGIH: 0.5 mg/m 3 (skin)

PROPERTIES:

Issue 1: 15 May 1989 Issue 2: 15 August 1994

solid; MP 190 °C; d 1.978 g/mL @ 22 °C; VP 16 Pa (0.12 mm Hg; 1700 mg/m 3) @ 100 °C

SYNONYMS: penta; PCP

SAMPLING SAMPLER:

FILTER + BUBBLER (mixed cellulose ester membrane with stainless steel backup screen/ethylene glycol)

FLOW RATE: 0.5 to 1.0 L/min

MEASUREMENT TECHNIQUE:

HPLC, UV DETECTION

ANALYTE:

pentachlorophenol

EXTRACTION:

10 mL methanol

VOL-MIN: -MAX:

48 L @ 0.5 mg/m 3 480 L

INJECTION VOLUME:

20 µL

SHIPMENT:

place filter in bubbler containing 15 mL ethylene glycol after sampling

MOBILE PHASE:

60% methanol/40% water, 1.5 mL/min

COLUMN:

µ-Bondapak C 18, 10-µm particle size, 30 cm x 3.9-mm ID

DETECTOR:

UV @ 254 nm

SAMPLE STABILITY:

at least 8 days @ 25 °C

BLANKS:

2 to 10 field blanks per set CALIBRATION: standard solutions of pentachlorophenol n i ethylene glycol and methanol ACCURACY RANGE:

RANGE STUDIED: BIAS:

0.265 to 1.130 mg/m 3 [1] (180-L samples) 3.0%

ˆ rT): 0.072 OVERALL PRECISION (S ACCURACY:

24 to 270 µg per sample [1]

ESTIMATED LOD: 8 µg per sample [2] PRECISION (Sr):

0.051 @ 45 to 180 µg per sample [1]

± 15% (12-28%)

APPLICABILITY: The working range is 0.13 to 11 mg/m 3 for a 180-L air sample. This method is also applicable to STEL measurements using a 15-L sample. The method has been used to sample for pentachlorophenol in the presence of 2,3,4,6tetrachlorophenol at a lumber yard [3].

INTERFERENCES: None identified.

OTHER METHODS: This revises Method S297 [2]. An independent analytical method provided by Vulcan Materials Co. [4] using a sampling train consisting of Zefluor filter and silica gel tube and HPLC analysis was used by a NIOSH contractor [5] f or analyzing samples containing pentachlorophenol.

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94