Page:NIOSH Manual of Analytical Methods - 5508.pdf/1

 KEPONE

C10 Cl10 O

MW: 490.68

METHOD: 5508, Issue 2

CAS: 143-50-0

5508

RTECS: PC8575000

EVALUATION: PARTIAL

OSHA : no standard NIOSH: 0.001 mg/m 3; carcinogen ACGIH: no standard

PROPERTIES:

Issue 1: 15 February 1984 Issue 2: 15 August 1994

solid; MP 350 °C (dec); VP <4 x 10 -5 Pa (3 x 10 -7 mm Hg; 8 µg/m 3) @ 25 °C

SYNONYMS: chlordecone, decachlorotetracyclodecanone

SAMPLING SAMPLER:

MEASUREMENT

FILTER + IMPINGER (0.8-µm cellulose ester membrane + impinger with 0.1 M NaOH)

TECHNIQUE:

GAS CHROMATOGRAPHY, ECD

ANALYTE:

Kepone

FLOW RATE:

0.5 to 1 L/min

RECOVERY FROM FILTER: 99:1 benzene:methanol, 10 mL; stand 2 h

VOL-MIN: -MAX:

50 L @ 1 µg/m 3 600 L

SHIPMENT:

routine

SAMPLE STABILITY:

at least 12 days @ 25 °C

FIELD BLANKS:

2 to 10 field blanks per set

ACCURACY RANGE STUDIED: BIAS:

RECOVERY FROM IMPINGER:

benzene, @ pH <7, two 5-mL portions

INJECTION VOLUME:

5 µL

TEMPERATURE-INJECTION: -DETECTOR: -COLUMN:

225 °C 335 °C 200 °C

CARRIER GAS:

nitrogen, 70 mL/min

COLUMN:

1.8 m x 4-mm glass; 3% OV-1 on 80/100 mesh Chromosorb WHP

CALIBRATION:

Kepone in 99:1 benzene:methanol

RANGE:

50 to 500 ng per sample

3

2.5 to 2.6 µg/m (376-L samples) not determined

ˆ ): 0.23 [1] OVERALL PRECISION (S rT ACCURACY:

> ± 45%

ESTIMATED LOD: 10 ng per sample PRECISION (Sr):

0.014 (filters); 0.060 (impingers)

APPLICABILITY: The working range is 0.001 to 25 mg/m 3 for 50-L air samples. Personal and area samples were collected by this method at a Mirex formulation plant.

INTERFERENCES: Partial conversion of Mirex into Kepone can occur by reaction with NaOH solution in the impinger and pH adjustment. A different column packing which may be used is 3% OV-210 on 80/100 mesh Chromosorb WHP.

OTHER METHODS: This method was originally designated P&CAM 225 [1,2].

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94