Page:NIOSH Manual of Analytical Methods - 5005.pdf/1

 THIRAM

((CH3)2NC(=S)S-)2

MW: 240.43

METHOD: 5005, Issue 2

5005

CAS: 137-26-8

RTECS: JO1400000

EVALUATION: FULL

OSHA : 5 mg/m 3 NIOSH: 5 mg/m 3; Group I Pesticide ACGIH: 1 mg/m 3

PROPERTIES:

Issue 1: 15 February 1984 Issue 2: 15 August 1994

white crystalline powder; d 1.29 g/mL; MP 155 °C; VP not significant

SYNONYMS: bis(dimethylthiocarbamoyl)disulfide; tetramethylthiuram disulfide; tetramethylthioperoxydicarbonic diamide

SAMPLING SAMPLER:

FILTER (1-µm PTFE membrane)

FLOW RATE:

1 to 4 L/min

VOL-MIN: -MAX:

10 L 400 L

SHIPMENT:

routine

SAMPLE STABILITY:

7 days at 25 °C

BLANKS:

2 to 10 field blanks per set

BULK SAMPLE:

desirable; 1 to 5g

MEASUREMENT TECHNIQUE:

HPLC, UV DETECTION

ANALYTE:

Thiram

EXTRACTION:

(filter) 10 mL CH 3CN, 30 min; (cassette top) 10 mL CH 3CN rinse

INJECTION VOLUME:

5 µL

MOBILE PHASE:

60% acetonitrile/40% water, 1 mL/min

COLUMN:

µ-Bondapak C 18 (30 cm x 3.9-mm-ID stainless steel); ambient temperature

DETECTOR:

UV @ 254 nm, 1-cm cell

CALIBRATION:

standard solutions of Thiram in acetonitrile

RANGE:

0.1 to 3 mg per sample [1]

ACCURACY RANGE STUDIED:

3 to 12 mg/m 3 [1] (240-L samples)

BIAS:

- 0.18%

ˆ ): 0.055 [1] OVERALL PRECISION (S rT ACCURACY:

ESTIMATED LOD: 0.005 mg per sample [1] PRECISION (Sr):

0.012 [1]

± 10.67%

APPLICABILITY: The working range is 0.5 to 15 mg/m 3 for a 200-L air sample. NIOSH researchers have used this method at facilities that use Thiram as an insecticide.

INTERFERENCES: None known.

OTHER METHODS: This is Method S256 [2] in a revised format. An earlier spectrophotometric method, P&CAM 228 [3], has not been revised because of excessive analytical variability [4].

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94