Page:NIOSH Manual of Analytical Methods - 5004.pdf/1

 HYDROQUINONE

HOC6H4OH

MW: 110.11

METHOD: 5004, Issue 2

CAS: 123-31-9 EVALUATION: FULL

OSHA : 2 mg/m 3 NIOSH: C 2 mg/m 3/15 min ACGIH: 2 mg/m 3

5004

RTECS: MX3500000 Issue 1: 15 February 1984 Issue 2: 15 August 1994

PROPERTIES: solid; MP 170 °C; BP 285 °C @ 730 mm; VP 0.0024 Pa (1.8 x 10 -5 mm Hg; 0.11 mg/m 3) @ 25 °C

SYNONYMS: 1,4-benzenediol; hydroquinol; quinol; 1,4-dihydroxybenzene.

SAMPLING SAMPLER:

FILTER (0.8-µm cellulose ester membrane)

FLOW RATE:

1 to 4 L/min

VOL-MIN: -MAX:

30 L @ 2 mg/m 3 180 L

FIELD TREATMENT:

transfer filter immediately to jar with 10 mL 1% acetic acid

SHIPMENT:

ship sample solutions

SAMPLE STABILITY:

at least 7 days @ 25 °C

BLANKS:

2 to 10 field blanks per set

MEASUREMENT TECHNIQUE:

HPLC, UV DETECTION

ANALYTE:

hydroquinone

EXTRACTION:

1% acetic acid, 10 mL

INJECTION VOLUME: 100 µL MOBILE PHASE:

1% acetic acid in H 2O; 1 mL/min

COLUMN:

25 cm x 4.6-mm ID Partisil 10-ODS, µ-Bondapack C 18 or equivalent; ambient temperature, 400 to 600 psi (2800-4100 kPa)

DETECTOR:

UV @ 290 nm

CALIBRATION:

solutions of hydroquinone in 1% aqueous acetic acid

RANGE:

0.06 to 0.8 mg per sample [2]

ESTIMATED LOD:

0.01 mg per sample [3]

PRECISION (Sr):

0.030 [1]

ACCURACY RANGE STUDIED:

0.8 to 4 mg/m 3 [1] (90-L samples)

BIAS:

4.4%

ˆ ): 0.061 OVERALL PRECISION (S rT ACCURACY:

± 15.0%

APPLICABILITY: The working range is 0.7 to 8 mg/m 3 for a 90-L air sample or 2 to 25 mg/m 3 for a 30-L air sample. This method can be used when significant concentrations of hydroquinone vapor are not present.

INTERFERENCES: None known. Hydroquinone is unstable on the collection media and must be stabilized immediately after collection by dissolution in 1% acetic acid.

OTHER METHODS: This is Method S57 [2] in a revised format. The method also appears in a NIOSH recommended standard [4].

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94