Page:NIOSH Manual of Analytical Methods - 2561.pdf/1

 (1) 2-(DIMETHYLAMINO)ETHANOL (2) 1-DIMETHYLAMINO-2-PROPANOL

FORMULAS: TABLE 1

MW: TABLE 1

METHOD: 2561, Issue 1

CAS: TABLE 1

EVALUATION: PARTIAL

RTECS: TABLE 1 Issue 1: 15 March 2003

PROPERTIES: Table 1

OSHA: no REL NIOSH: no PEL ACGIH: no TLV COMPOUNDS:

2561

(1) 2-(dimethylamino)ethanol: dimethylethanol amine (2) 1-dimethylamino-2-propanol: dimethylisopropanolamine SAMPLING

SAMPLER:

SOLID SORBENT TUBE (XAD-7, 60 mg/30 mg)

FLOW RATE:

0.02 to 0.1 L/min

VOL – MIN: – MAX:

10 L 24 L

SHIPMENT:

Cold

SAMPLE STABILITY:

Stable stored in freezer

BLANKS:

2 to 10 field blanks per set

MEASUREMENT TECHNIQUE:

GAS CHROMATOGRAPHY, FID

ANALYTE:

Compounds above

DESORPTION:

1 mL methanol, 60 min

INJECTION VOLUME:

1 µL

TEMPERATURE -INJECTION: 250 °C -DETECTOR: 300 °C -COLUMN: 70 °C for 6 min then up to 200 °C for 4 minutes at a rate of 15 °C per minute CARRIER GAS: Helium, 1-2 mL/min

ACCURACY RANGE STUDIED:

Not studied

BIAS:

Not determined

COLUMN:

Capillary, fused silica, 30-m x 0.25-mm ID; 1.0-µm film dimethylpolysiloxane, DB-1 or equivalent

CALIBRATION:

Solutions of compounds in methanol

OVERALL PRECISION (S r t):

Not determined

RANGE:

0.004 to 2 mg per sample [1, 2, 3]

ACCURACY:

Not determined

ESTIMATED LOD:

See Table 2

PRECISION ( þ r ): See Table 2 APPLICABILITY: This method can be used for simultaneous analysis of both amino compounds. The method was field tested for almost 300 samples containing both compounds with little or no breakthrough [2, 3]. Up tp 4 mg of dimethylethanolamine (no isopropanolamine present) and up to 1200 :g dimethylisopropanol (140 :g dimethylethanolamine present) were reported on the field samples with little breakthrough. For higher capacity, a larger XAD-7 sorbent bed tube can be used. NOTE: During method development, a capillary Rtx-5Amine (cross-linked 5% diphenyl/95% dimethyl polysiloxane) column with deactivated injection port liner was also used successfully.

INTERFERENCES: None identified.

OTHER METHODS: This method may be applicable to other amino alcohols such as those in method 2007 [4 ].

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition