Page:NIOSH Manual of Analytical Methods - 2555.pdf/1

 KETONES I

Formulas: See Table 1

MW: Table 1

METHOD: 2555, Issue 1

(1) (2) (3) (4) (5) (6) (7)

CAS: Table 1

PROPERTIES:

Issue 1: 15 March 2003 See Table 3

Acetone: dimethyl ketone, ketone propane, 2-propanone. Methyl ethyl ketone: methyl acetone, 2-butanone, MEK. 2-Pentanone: ethyl acetone, methyl propyl ketone, MPK. Methyl isobutyl ketone: hexone, 4-methyl-2-pentanone, MIBK. 2-Hexanone: methyl n-butyl ketone, methyl butyl ketone, MBK. Di-isobutyl ketone: sym-diisopropyl acetone, 2,6-dimethyl-4-heptanone, isovalerone, valerone, DIBK. Cyclohexanone: anone, cyclohexyl ketone, pimelic ketone.

SAMPLING SAMPLER:

RTECS: Table 1

EVALUATION: PARTIAL

OSHA : See Table 2 NIOSH: See Table 2 ACGIH: See Table 2 SYNONYMS:

2555

SOLID SORBENT TUBE (Anasorb CMS, 150 mg/75 mg)

MEASUREMENT TECHNIQUE:

GAS CHROMATOGRAPHY, FID

ANALYTE:

See Table 1

DESORPTION:

1 mL CS2 for 30 minutes

INJECTION VOLUME:

1 µL

250°C 300°C 40°C (1 min) to 200°C (8°C/min)

FLOW RATE: 0.01 to 0.2 L/min

VOL-MIN: -MAX:

Acetone 0.5 L 3.0 L

SHIPMENT:

Refrigerate samples.

Others 1L 10 L

SAMPLE STABILITY:

All analytes 30 days @ 5°C

TEMPERATURE -INJECTION: -DETECTOR: -COLUMN:

BLANKS:

2 to 10 field blanks per set.

CARRIER GAS:

Helium, 1mL/min

COLUMN:

Capillary, fused silica, 30 m x 0.53-mm ID, 3.00-µm film crossbonded® 35% diphenyl - 65% dimethyl polysiloxane

CALIBRATION:

Standard solutions of analytes in CS 2

RANGE:

See Table 4.

ACCURACY RANGE STUDIED:

Not studied.

BIAS:

Not determined.

OVERALL PRECISION ( Ö r T ):

Not determined.

ACCURACY:

Not determined.

ESTIMATED LOD: See Table 4. PRECISION ( þ r ):

See Table 4.

APPLICABILITY: For three-liter sample, the working range for acetone was 0.378 to 41.4 ppm (0.92 to 100.2 mg/m3 ). For a 10-L sample the working range for methyl ethyl ketone was 0.092 to 10.2 ppm (0.275 to 30.5 mg/m3 ), for 2-pentanone was 0.077 to 8.67 ppm (0.276 to 31.1 mg/m3 ), for methyl isobutyl ketone was 0.066 to 6.83 ppm (0.275 to 28.5 mg/m3 ), for 2hexanone was 0.066 to 7.45 ppm (0.275 to 31.1 mg/m3 ), for diisobutyl ketone was 0.052 to 5.07 ppm (0.308 to 30.1 mg/m3 ), and for cyclohexanone was 0.075 to 9.79 ppm (0.300 to 39.2 mg/m3 ). INTERFERENCES: Any compounds with similar retention times as the analytes of interest. Alternate columns include Rtx-1 and Rtx-5 or equivalent capillary columns. OTHER METHODS: This method was developed as part of an update for NMAM 1300, issue 2 (dated 15 August 1994) [1]. NMAM 1300, issue 2 was based on NIOSH Manual of Analytical Methods, 2nd edition methods S1, S18, S19, S20, S178, and S358. This method includes: lower LOD/LOQ values for each analyte, improved DE recovery results for each analyte (at lower levels), inclusion of methyl ethyl ketone and methyl isobutyl ketone in the method by the use of a different sorbent tube (Anasorb CMS), a 30-day storage stability study, and replacement of the packed column with a Rtx-35 fused silica capillary column.

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition