Page:NIOSH Manual of Analytical Methods - 2546.pdf/3

 CRESOL (all isomers) and PHENOL: METHOD 2546, Issue 1, dated 15 August 1994 - Page 3 of 4 10.

Analyze three quality control blind spikes and three analyst spikes to insure that the calibration graph and DE graph are in control.

MEASUREMENT: 11.

12.

Set gas chromatograph according to manufacturer's recommendations and to conditions given on page 2000-1. Inject 1-µL sample aliquot manually using solvent flush technique or with autosampler. NOTE: If peak area is above the linear range of the working standards, dilute with methanol, reanalyze, and apply the appropriate dilution factor in calculations. Measure total peak area of the two analyte peaks.

CALCULATIONS: 13.

14.

Determine the mass, µg (corrected for DE) of cresols and phenol found in the sample front (W f) and back (W b) sorbent sections, and in the average media blank front (B f) and back (B b) sorbent sections. NOTE: If W b > W f/10, report breakthrough and possible sample loss. Calculate concentration, C, of cresols in the air volume sampled, V (L):

EVALUATION OF METHOD: This is a modification of OSHA Method 32 (Phenol and Cresol) which uses the same sampling procedure [1]. Phenol and all cresol isomers were easily resolved by capillary GC using a split injection ratio of 20:1. The desorption efficiency (DE) results for all analytes were > 0.90. Analytes were stable for 30 days when refrigerated.

REFERENCES: [1] Phenol and Cresol, Occupational Safety and Health Administration, OSHA Method 32, OSHA Analytical Laboratory, 1981. [2] NIOSH Manual of Analytical Methods, 3rd ed., Vol. 2, Method 3502, U.S. Dept. of Health, Education, and Welfare, Publication #84-100 (NIOSH), 1984. [3] Ibid, Method 2001. [4] DataChem Laboratories Report, Seq. #7478-L (NIOSH, unpublished, May 8, 1992). [5] NIOSH/OSHA, Occupational Health Guidelines for Chemical Hazards, USDHHS (NIOSH), Publ. 81123 (1981). [6] Pendergrass, S.M., An Improved Method for the Sampling and Analysis of Phenol and o-, m-, and p-Cresol by Capillary GC/FID, Amer. Ind. Hyg. Assoc. J. (accepted for publication, 1994). [7] Gessner, H., Ed., Condensed Chemical Dictionary, 10th ed., Van Nostrand Reinhold, 1981.

METHOD REVISED BY: Stephanie M. Pendergrass, NIOSH/DPSE.

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94