Page:NIOSH Manual of Analytical Methods - 2546.pdf/1

 CRESOL (all isomers) and PHENOL

CH3C6H4OH C6H5OH

MW: 108.14 94.11

METHOD: 2546, Issue 1

CAS: 1319-77-3 108-95-2

2546

RTECS: GO5950000 SJ3325000

EVALUATION: PARTIAL

OSHA : Table 1 NIOSH: ACGIH:

Issue 1: 15 August 1994

PROPERTIES: Table 1

SYNONYMS: o-cresol: 2-methylphenol; CAS #95-48-7; m-cresol: 3-methylphenol; CAS #108-39-4; p-cresol: 4-methylphenol; CAS phenol: carbolic acid; hydroxybenzene SAMPLING SAMPLER:
 * 1) 106-44-5.

SOLID SORBENT TUBE (XAD-7, 100 mg/50 mg)

FLOW RATE:

0.01 to 0.1 L/min

VOL-MIN: -MAX:

1 L @ 5 ppm 24 L

SHIPMENT:

routine

MEASUREMENT TECHNIQUE:

GAS CHROMATOGRAPHY, FID

ANALYTE:

cresol isomers/phenol

DESORPTION:

2 mL methanol; sonicate

INJECTION VOLUME:

1 µL (split 20:1)

SAMPLE STABILITY:

at least 1 week @ 25 °C [1]

TEMPERATURE-INJECTION: -DETECTOR: -COLUMN:

BLANKS:

2 to 10 field blanks per set

CARRIER GAS:

He, 1 mL/min

COLUMN:

Stabilwax DA fused silica capillary, 30 m, 0.32-mm ID, 0.25-mm film or equivalent

CALIBRATION:

standard solutions of analytes in methanol 20 to 800 µg per sample

ACCURACY

250 °C 300 °C 160 - 225 °C (3 °C/min)

RANGE STUDIED:

not studied

RANGE:

BIAS:

not determined

ESTIMATED LOD: 1 to 3 µg per sample

ˆ rT): not determined OVERALL PRECISION (S ACCURACY:

PRECISION (Sr):

0.028 [1]

not determined

APPLICABILITY: The working range is 0.25 to 15 ppm (1 to 60 mg/m 3) for cresols and phenol in a 20-L air sample.

INTERFERENCES: None identified. A DB-wax fused silica capillary column is an alternate column.

OTHER METHODS: This method uses a sampler similar to that of OSHA 32 [1] and replaces methods 2001 (Cresols) [2] and 3502 (Phenol) [3]. Analysis of the sample extracts can also be done by HPLC/UV [1,4].

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94