Page:NIOSH Manual of Analytical Methods - 2540-1.pdf/1

 TRIETHYLENETETRAMINE See ETHYLENEDIAMINE, Method 2540, for Procedure (NH2CH2CH2NHCH2)2

MW: 146.2

METHOD: 2540, Issue 2

CAS: 112-24-3

RTECS: YE6650000

EVALUATION: UNRATED

OSHA : no PEL NIOSH: no REL ACGIH: no TLV (1 ppm = 5.98 mg/m 3)

PROPERTIES:

Issue 1: 15 May 1989 Issue 2: 15 August 1994

liquid; d 0.98 g/mL @ 20 °C; BP 277.4 °C; VP unknown; flash point 118 °C

SYNONYMS: triethylenetetramine: TETA; trientine; N,N-bis(2-aminoethyl)-1,2-diaminoethane; 3,6-diazaoctane-1,8-diamine

SAMPLING SAMPLER:

MEASUREMENT TECHNIQUE:

HPLC, UV DETECTION

ANALYTE:

naphthylisothiourea derivative of analytes

FLOW RATE: 0.01 to 0.1 L/min [1]

DESORPTION:

2 mL dimethylformamide (DMF), ultrasonic 30 min

VOL-MIN: -MAX:

1 L @ 10 ppm 20 L

INJECTION VOLUME: 10 µL

SHIPMENT:

routine

COLUMN:

10-µm radial cyano, 10 cm x 8-mm ID in Waters RCM-100 radial compression mode

MOBILE PHASE:

50/50 isoctane/isopropanol at 3 mL/min

CALIBRATION:

standard solutions of derivatives in DMF

SAMPLE STABILITY: BLANKS:

SOLID SORBENT TUBE (1-naphthylisothiocyanatecoated XAD-2, 80 mg/40 mg)

>30 days @ 20 °C [2] 2 to 10 field blanks per set

ACCURACY

RANGE: 0.016 to 8 mg/m 3; (10-L samples)

RANGE STUDIED:

ˆ ): OVERALL PRECISION (S rT

1 to 119 µg per sample

ESTIMATED LOD: 0.3 µg per sample PRECISION (Sr):

0.018

0.06 [1]

BIAS:

-1.9%

ACCURACY:

±13.7%

APPLICABILITY: The working range for TETA is 0.08 to 160 mg/m 3 for a 10-L air sample. This method is the result of evaluation [2] of OSHA Method #60 for DETA, EDA, TETA [1]. The theoretical capacity of each front section is 1.6 mg of TETA.

INTERFERENCES: Other primary or secondary amines may react with the sampler coating reagent, and thereby reduce the sampler capacity.

OTHER METHODS: This replaces NIOSH Method P&CAM 276 [3]. The method of Anderson, et al., for EDA [4] is an alternate method using thiourea derivatization and HPLC analysis.

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94