Page:NIOSH Manual of Analytical Methods - 2531.pdf/1

 GLUTARALDEHYDE

O=CH(CH2)3CH=O

MW: 100.12

METHOD: 2531, Issue 2

CAS: 111-30-8

2531

RTECS: MA2450000

EVALUATION: FULL

OSHA : C 0.2 ppm NIOSH: C 0.2 ppm; Group I Pesticide ACGIH: C 0.2 ppm (1 ppm = 4.09 mg/m 3 @ NTP)

PROPERTIES:

Issue 1: 15 May 1989 Issue 2: 15 August 1993

oil; d 0.72 g/mL @ 20 °C; BP 188 °C; MP - 14 °C; VP 2.2 kPa (17 mm Hg) @ 20 °C

SYNONYMS: glutaric dialdehyde; 1,5-pentanedial.

SAMPLING SAMPLER:

FLOW RATE:

SOLID SORBENT TUBE (10% 2-(hydroxymethyl)piperidine on XAD2, 120 mg/60 mg: Supelco ORBO-23 or equivalent) 0.01 to 0.08 L/min, or 0.2 L/min for 20 min

VOL-MIN: -MAX:

4 L @ 0.2 ppm 39 L

SHIPMENT:

routine

SAMPLE STABILITY:

at least 5 weeks @ 25 °C [1]

FIELD BLANKS:

2 to 10 field blanks per set

MEASUREMENT TECHNIQUE:

GAS CHROMATOGRAPHY, FID

ANALYTE:

oxazolidine derivative of glutaraldehyde

DESORPTION:

2 mL toluene; 60 min ultrasonic

INJECTION VOLUME:

1 µL splitless; split vent time 30 s

TEMPERATURE-INJECTION: -DETECTOR: -COLUMN:

CARRIER GAS:

He, 0.5 mL/min; makeup 2.9 mL/min

COLUMN:

capillary, 10 m x 0.25-mm, 5% phenyl, 95% methyl polysiloxane (DB-5 or equivalent)

CALIBRATION:

standard glutaraldehyde solutions spiked on sorbent

RANGE:

3 to 180 µg per sample [1]

MEDIA BLANKS: 10 per set

ACCURACY RANGE STUDIED:

0.8 to 9 mg/m 3 [1] (22-L samples)

BIAS:

0.3%

ˆ ): 0.087 [1] OVERALL PRECISION (S rT ACCURACY:

250 °C 280 °C 1 min @ 70 °C; 20 °C/min; hold 2 min @ 290 °C

ESTIMATED LOD: 1 µg per sample [2] PRECISION (Sr):

0.093 [2] @ 5 to 50 µg per sample [1]

± 17.4%

APPLICABILITY: The working range is 0.03 to 2 ppm (0.14 to 8 mg/m 3) for a 22-L air sample; the method is sensitive enough for ceiling determinations. The method is suitable for the simultaneous determination of furfural and glutaraldehyde.

INTERFERENCES: None have been observed.

OTHER METHODS: This is a new method. A wide-bore 10-m capillary column is an alternate chromatographic column.

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/93