Page:NIOSH Manual of Analytical Methods - 2528.pdf/1

 2-NITROPROPANE (CH3)2CHNO2

MW: 89.09

METHOD: 2528, Issue 2

2528

CAS: 79-46-9

RTECS: TZ550000

EVALUATION: FULL

OSHA : 25 ppm NIOSH: lowest feasible; suspect carcinogen; Group I Pesticide ACGIH: 10 ppm; suspect carcinogen (1 ppm = 3.64 mg/m 3 @ NTP)

PROPERTIES:

Issue 1: 15 August 1987 Issue 2: 15 August 1994

liquid; d 0.9821 g/mL @ 25 °C; BP 120 °C; MP -91 °C; VP 2.4 kPa (18 mm Hg; 2.4% v/v) @ 25 °C; lower explosive limit 2.6% (v/v) in air

SYNONYMS: dimethylnitromethane; sec-nitropropane.

SAMPLING

MEASUREMENT

SAMPLER:

SOLID SORBENT TUBE (Chromosorb 106, 100 mg/50 mg)

TECHNIQUE:

GAS CHROMATOGRAPHY, FLAME IONIZATION DETECTOR

FLOW RATE:

0.01 to 0.05 L/min

ANALYTE:

2-nitropropane

VOL-MIN: -MAX:

0.1 L @ 25 ppm 2 L [1]

DESORPTION:

1 mL ethyl acetate; stand 30 min

SHIPMENT:

routine

INJECTION VOLUME:

5 µL

100% recovered after 7 days @ 25 °C + 21 days @ 0 C [1]

TEMPERATURE-INJECTION: -DETECTOR: -COLUMN:

2 to 10 field blanks per set

CARRIER GAS:

He or N 2, 20 mL/min

COLUMN:

stainless steel, 6-m x 4-mm ID, packed with 10% FFAP on 80/100 mesh Chromosorb WHP

CALIBRATION:

standard solution of 2-nitropropane in ethyl acetate

RANGE:

10 to 150 µg per sample [1]

SAMPLE STABILITY:

BLANKS:

ACCURACY RANGE STUDIED:

BIAS:

3.1 to 28.3 mg/m 3 (3-L samples) [1]

190 C 200 C 90 C

2.8% [1]

ˆ ): 0.05 [1] OVERALL PRECISION (S rT ESTIMATED LOD: 1 µg per sample [1] ACCURACY:

± 11.4% PRECISION (Sr):

0.03 @ 0.01 to 0.1 mg per sample [1]

APPLICABILITY: The working range is 1.4 to 27 ppm (5 to 100 mg/m 3) for a 2-L air sample.

INTERFERENCES: The method has been evaluated in epoxy spray paint operations with no apparent interference from methyl butyl ketone, heptane, 1-nitropropane, toluene and xylene [2]. The Chromosorb 106 must be extracted with acetone [1]; ot herwise autosampler needles will be readily plugged.

OTHER METHODS: This revises P&CAM 272 [3].

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94