Page:NIOSH Manual of Analytical Methods - 2522.pdf/1

 NITROSAMINES

Table 1

MW: Table 1

METHOD: 2522, Issue 2

2522

CAS: Table 1

RTECS: Table 1

EVALUATION: PARTIAL

OSHA : no PELs; N-nitrosodimethylamine is a carcinogen NIOSH: no RELs; N-nitrosodimethylamine is suspect carcinogen ACGIH: no TLVs; N-nitrosodimethylamine is suspect carcinogen

Issue 1: 15 May 1989 Issue 2: 15 August 1994

PROPERTIES: Table 1

SYNONYMS: Table 1.

SAMPLING SAMPLER:

SOLID SORBENT TUBE (Thermosorb/N™ air sampler)

FLOW RATE:

0.2 to 2 L/min

VOL-MIN: -MAX:

15 L @ 10 µg/m 3 1000 L

SHIPMENT:

routine

SAMPLE STABILITY:

at least 6 weeks @ 20 °C [1,2]

BLANKS:

2 to 10 field blanks per set

MEASUREMENT TECHNIQUE:

GAS CHROMATOGRAPHY, TEA [1]

ANALYTE:

nitrosamines (Table 1)

DESORPTION:

2 mL 3:1 (v/v) dichloromethane/ methanol; stand 30 min

INJECTION VOLUME: COLUMN:

5 µL stainless steel (10 in x in ); 10% Carbowax 20M + 2% KOH on Chromosorb W-AW

TEMPERATURE-INJECTION: -DETECTOR: -COLUMN:

GASES:

N 2 carrier, 25 mL/min; oxygen, 5 mL/min; ozone, 0.2 mL/min

CALIBRATION:

standard solutions of analytes in methanol/dichloromethane

RANGE:

0.15 to 0.5 µg per sample [2]

ACCURACY RANGE STUDIED:

not studied

BIAS:

not determined

200 °C 550 °C to 600 °C 110 °C to 200 °C programmed @ 5°/min

ˆ ): not determined OVERALL PRECISION (S rT ESTIMATED LOD: 0.05 µg per sample [2] ACCURACY:

not determined PRECISION (Sr):

0.014 @ 0.05 to 0.4 µg per sample [2]

APPLICABILITY: The working range is 0.003 to 10 mg/m 3 for a 50-L air sample. If high ambient concentrations of nitrosamines are expected, another Thermosorb/N tube should be used as a back-up in sampling.

INTERFERENCES: When the thermal energy analyzer (TEA) is operated in the nitrosamine mode, it is highly specific for N-nitroso compounds. Because of the TEA's selectivity and sensitivity, it is possible to chromatograph and quantitate N-nitroso compounds, even in the presence of other co-eluting compounds. Therefore, there is little or no interference from other compounds.

OTHER METHODS: This replaces NIOSH methods P&CAM 252 [3] and P&CAM 299 [4].

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94