Page:NIOSH Manual of Analytical Methods - 2506.pdf/1



ACETONE CYANOHYDRIN	2506 (CH3)2C(OH)CN   MW: 85.11   CAS: 75-86-5   RTECS: OD9275000 METHOD: 2506, Issue 2

EVALUATION: PARTIAL

OSHA:	 no PEL NIOSH:	C 1 ppm/15 min ACGIH:	 no TLV (1 ppm = 3.48 mg/m³

Issue 1:	15 May 1985 Issue 2:	15 August 1994

PROPERTIES:	 liquid; d 0.932 g/mL @ 19 °C; BP 95 °C; MP −19 °C; VP 110 Pa (0.8 mm Hg) @ 20 °C

SYNONYMS:	 2-cyano-2-propanol; 2-methyllactonitrile; 2-hydroxy-2-methylpropanenitrile SAMPLING

MEASUREMENT

SAMPLER:	 SOLID SORBENT TUBE (Porapak QS, 100 mg/50 mg)

TECHNIQUE:

GAS CHROMATOGRAPH, NP (THERMIONIC) DETECTOR

FLOW RATE:	 0.2 L/min

ANALYTE:

acetone cyanohydrin

VOL-MIN: -MAX:

DESORPTION:

1 mL ethyl acetate; ultrasonicate 60 min

SHIPMENT:	 in refrigerated container @ 0 °C

INJECTION VOLUME:

5 µL, 1 µL flush

SAMPLE STABILITY:	 at least 5 days if stored at @ 0 °C immediately following collection

TEMPERATURE-INJECTION:	100 °C -DETECTOR:	100 °C -COLUMN:	70 °C

BLANKS:

CARRIER GAS:

N2, 33 mL/min

COLUMN:

PTFE, 2 m × 3.2-mm OD, packed with 5% OV-17 on 40/60 mesh Chromosorb T (APPENDIX)

CALIBRATION:

solutions of acetone cyanohydrin in ethyl acetate

OVERALL PRECISION :	0.093 [1]

RANGE:

1 to 50 µg per sample

ACCURACY:

ESTIMATED LOD:	 0.1 µg per sample [1]

0.3 L @ 1 ppm 12 L

2 to 10 field blanks per set ACCURACY

RANGE STUDIED:

0.33 to 16.7 mg/m³ [1] (3-L samples)

BIAS:

not determined

not determined

PRECISION :

0.042 [1]

APPLICABILITY: The working range is 0.1 to 4.8 ppm (0.33 to 17 mg/m³) for a 3-L air sample. However, coadsorbed water vapor will decompose the analyte unless the samples are refrigerated immediately after collection. INTERFERENCES: Acetone, methyl methacrylate and methanol do not interfere with the analysis. Methacrylamide does not elute from the column under the conditions given above. The gas chromatograph must be modified to eliminate contact of analyte with heated glass or metal surfaces. OTHER METHODS: This method was originally designated P&CAM 340 [2].

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition