Page:NIOSH Manual of Analytical Methods - 2014.pdf/1

 p-CHLOROPHENOL

C6H4ClOH

MW: 128.56

METHOD: 2014, Issue 2

CAS: 106-48-9 EVALUATION: FULL

OSHA : no PEL NIOSH: no REL ACGIH: no TLV (1 ppm = 5.26 mg/m 3 @ NTP)

PROPERTIES:

2014

RTECS: SK2800000 Issue 1: 19 September 1980 Issue 2: 15 August 1994

crystals; d 1.224 g/mL @ 20 °C; MP 43.243.7 °C; BP 220 °C; VP 0.013 kPa (0.1 mm Hg) @ 20 °C; flash point 121 °C (closed cup)

SYNONYMS: 4-chlorophenol; 4-chloro-1-hydroxybenzene

SAMPLING SAMPLER:

SORBENT TUBE (silica gel, 150 mg/75 mg)

FLOW RATE:

0.05 - 0.2 L/min

VOL-MIN: -MAX:

1.5 L @ 1 ppm 40 L

SHIPMENT:

Routine

SAMPLE STABILITY:

7 days @ 25 °C at least 29 days @ 0 °C [1]

BLANKS:

2 to 10 field blanks per set

ACCURACY RANGE STUDIED:

0.910 to 23.4 mg/m 3 [1] (3-L samples)

BIAS:

none identified

ˆ rT): OVERALL PRECISION (S

0.061 for range studied [1]

ACCURACY:

± 15% (12-28%)

MEASUREMENT TECHNIQUE:

HPLC/UV

ANALYTE:

p-chlorophenol

EXTRACTION:

1 mL acetonitrile

INJECTION VOLUME:

100 µL

MOBILE PHASE:

30% acetonitrile, 70% water to 80% acetonitrile/20% water in 20 minutes, 1 mL/min

COLUMN:

C18. (5 µm particle size, 4-mm ID by 30cm long stainless steel)

DETECTOR:

UV, 280 nm

CALIBRATION:

p-chlorophenol in 30% (v/v) acetonitrile in water

RANGE:

8 to 64 µg/sample [1]

ESTIMATED LOD: 2.5 µg/sample [1] PRECISION (Sr):

0.024 [1]

APPLICABILITY: The working range is 0.15 to 53 ppm (0.8 to 280 mg/m 3) for a 10-L air sample.

INTERFERENCES: None identified. The chromatographic conditions described will separate phenol ; o-chlorophenol; 2,3-, 2,4-, 2,5-, 2,6-, 3,4-, and 3,5- dichlorophenol; o- and p-nitrophenol; 2,4-dimethylphenol; 2,4,5-trichlorophenol; 4-chloro- o-methylphenol; 2,4-dinitrophenol; 4,6-dinitro-2-methylphenol; and pentachlorophenol.

OTHER METHODS: This method replaces P&CAM 337 [2]. The other columns for the analysis of p-chlorophenol have been reported in the literature [3-5].

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94