Page:NIOSH Manual of Analytical Methods - 1454.pdf/1

 ISOPROPYL ACETATE

CH3COOCH(CH3)2

MW: 102.14

METHOD: 1454, Issue 1

CAS: 108-21-4

EVALUATION:

OSHA : 250 ppm NIOSH: no REL ACGIH: 250 ppm; STEL 310 ppm (1 ppm = 4.18 mg/m 3 @ NTP)

1454

RTECS: AI4930000

PARTIAL

PROPERTIES:

Issue 1: 15 August 1994

colorless liquid; BP 89.4 °C; d 0.87 g/mL @ 20 °C; miscible in most organic solvents; VP 6.33 kPa (47.5 mm Hg) @ 20 °C

SYNONYMS: methyl isobutyl acetate

SAMPLING SAMPLER:

CHARCOAL TUBE (coconut shell charcoal, 100 mg/50 mg)

FLOW RATE:

0.02 to 0.2 L/min

VOL-MIN: -MAX:

0.1 L @ 250 ppm 9L

SHIPMENT:

routine

MEASUREMENT TECHNIQUE:

GAS CHROMATOGRAPHY, FID

ANALYTE:

isopropyl acetate

DESORPTION:

carbon disulfide, 1 mL

INJECTION VOLUME:

5 µL

SAMPLE STABILITY:

not documented

TEMPERATURE-INJECTION: -DETECTOR: -COLUMN:

225 °C 250 °C 60 °C - isothermal

BLANKS:

2 to 10 field blanks per set

CARRIER GAS:

helium, 30 mL/min

COLUMN:

10 ft x 1/8-inch stainless steel, packed with 5% FFAP on 100/120 mesh Supelcoport [1]

CALIBRATION:

standard solutions of isopropyl acetate in carbon disulfide

RANGE:

0.05 to 15 mg per sample [1]

ACCURACY RANGE STUDIED:

446 to 1870 mg/m 3 [1] (8-L samples)

BIAS:

1.1%

ˆ ): 0.067 [1] OVERALL PRECISION (S rT ACCURACY:

±29.4%

ESTIMATED LOD: 0.01 mg per sample [1] PRECISION (Sr):

0.007 @ 3.6 to 15 mg per sample [1]

APPLICABILITY: The working range is 1.5 to 450 ppm (6 to 1870 mg/m 3) for an 8-L air sample.

INTERFERENCES: None identified.

OTHER METHODS: This is NIOSH Method S50 in a revised format [1]. Operational modifications [2] to this method are as follows: column - 30 m x 0.3-mm I.D. fused silica WCOT capillary coated with 1.0-µm DB-1. Column temperature - 45 °C for 16 min, and programmed at 16 °C/min to 150 °C and held for 8 min. Carrier gas - He, with split ratio of 1:10. Desorption - 1 h or more in 1 mL carbon disulfide with 1 µL/mL p-cymene as internal standard.

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94