Page:NIOSH Manual of Analytical Methods - 1451.pdf/1

 METHYL CELLOSOLVE ACETATE

CH3COOCH2CH2OCH3

MW: 118.15

METHOD: 1451, Issue 2

CAS: 110-49-6

EVALUATION: FULL

OSHA : 25 ppm (skin) NIOSH: 0.1 ppm (skin) ACGIH: 5 ppm (skin) (1 ppm = 4.83 mg/m 3 @ NTP)

1451

PROPERTIES:

RTECS: KL5950000

Issue 1: 6 December 1974 Issue 2: 15 August 1994

liquid; BP 145 °C; MP -65 °C; Flash point 49 °C; d 1.005 @ 20 °C; VP 2 mm Hg (1700 mg/m 3) @ 20 °C

SYNONYMS: 2-methoxyethyl acetate; glycol monomethyl ether acetate; ethylene glycol monomethyl ether acetate

SAMPLING SAMPLER:

SOLID SORBENT TUBE (coconut shell charcoal, 100 mg/50 mg)

FLOW RATE:

0.01 to 0.2 L/min

VOL-MIN: -MAX:

0.2 L @ 25 ppm 20 L

SHIPMENT:

routine

MEASUREMENT TECHNIQUE:

GAS CHROMATOGRAPHY, FID

ANALYTE:

methyl cellosolve acetate

EXTRACTION:

carbon disulfide, 1 mL

INJECTION VOLUME:

5 µL

SAMPLE STABILITY:

at least 15 days @ 0 °C [1]

TEMPERATURE-INJECTOR: -DETECTOR: -COLUMN:

225 °C 250 °C 90 °C

BLANKS:

2 to 10 field blanks per set

CARRIER GAS:

helium, 30 mL/min

COLUMN:

10 ft x 1/8-in stainless steel packed with 5% FFAP stationary phase on 100/200 mesh Supelcoport

CALIBRATION:

standard solutions of methyl cellosolve acetate in carbon disulfide

RANGE:

30 to 4500 µg per sample [2]

ACCURACY RANGE STUDIED:

51 to 214 mg/m 3 [2] (20-L samples)

BIAS:

- 0.4%

ˆ ): OVERALL PRECISION (S rT

0.078 [2]

ACCURACY:

± 13.3%

ESTIMATED LOD: 10 µg per sample [2] PRECISION (Sr):

0.0441 [2]

APPLICABILITY: The working range is 0.3 to 47 ppm (1.5 to 225 mg/m 3) for a 20-L air sample. Better sensitivity may be achieved if a capillary column is used in place of a packed column. A 30-m x 0.32-mm fused silica capillary column coate d internally with 1.0 µm of DB-5, with appropriate instrument conditions, is recommended.

INTERFERENCES: High humidity conditions may cause inefficient collection of organic vapors.

OTHER METHODS: This is an adaptation of NIOSH Method S39 [2] and OSHA Method 53, issued 1/85. [1] Operational modifications [3] to the OSHA method are as follows: column -30 m x 0.32-mm I.D. fused silica capillary coated with 1.0 µm DB-5. Column temperature: 40 °C for 4 min and programmed at 4 °C/min. to 85 °C. Desorption: 30 min in 1.0 mL methylene chloride/methanol, 95/5(v/v) containing 1 µL/mL toluene as internal standard.

NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94