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 constituents were shown to be mild irritants to the skin and eyes of experimental animals. One study [Anderson 1992] stated that CCP from an unspecified source acted as both a sensory and pulmonary irritant in mice.

In summary, more than 300 substances and various combinations of materials were included in the animal studies. Of 238 tested for skin irritation, 8 were positive. In addition, some materials caused mild, transient irritation (25.2%; 60/238) but did not satisfy FDA's regulatory definition of an irritant. In 129 dermal lethality tests, mild skin irritation was noted (17.8%; 23/129); however, the regulatory definition is not based on this type of test. No pattern was observed to identify the CCP component responsible for the mild skin irritation reported in humans. A total of 271 substances were tested in the allergic contact dermatitis animal model, and 13 were positive. This result suggests that CCP infrequently causes allergic contact dermatitis in animals. Whether materials with positive toxicological outcomes were actually marketed is unclear; but the general rationale for toxicity testing is to prevent the marketing of materials that may harm users.

Most of the toxicological data submitted to the NIOSH docket were coded by the manufacturers for proprietary reasons. Thus it was not possible to identify replicate tests or the nature of the test materials or their means of preparation (dry, aqueous, neet, etc.). However, the animal toxicology results indicate only mild and transitory effects with liquids, and end users would not be exposed to the liquids.