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120 THAT I may dispatch as much as possible in a few Words, it now lies before me to describe the common Method of its Eruption; in the Beginning is a sharp pricking Pain upon the Part affected, which in a little Time grows very hot, and then lifts up the Cuticle into a Blister, containing a thin Ichor; but after the Vesicle is by rubbing or any other Accident broke, and the contained Fluid by Heat dissipated, its caustick Quality leaves an Eschar behind, which crusts over, in some sooner, and in others late; its Extension is various, sometimes more broad, and at others more contracted; nor is its Colour more certain; in the greatest Degree of Inflammation it is extreamly red, but for the most Part it is dusky, very often livid, and sometimes, from the peculiar Virulence of the pestilential Poison, even quite black.

BUT as there is a Quality in the pestilential Venom not yielding even to an actual Cautery, and from which, in the Production of Carbuncles, Eschars are generated, I take it to be of Consequence to know how such a sharp, burning, and caustick Humour comes to be bred in an humane Body; and by what Contrivance of Nature it comes to be thus separated and thrown out?